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NMDAR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21328 | UK-240455 | 178908-09-3 | UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. |
| CSN24287 | Traxoprodil mesylate | 189894-57-3 | Traxoprodil a selective antagonist of the NR2B subunit of the NMDA receptor. |
| CSN21414 | Transcrocetin meglumine salt | N/A | Transcrocetin meglumine salt, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. |
| CSN26714 | Transcrocetinate disodium | 591230-99-8 | Trans-crocetin sodium, also known as Transcrocetinate sodium or Sodium crocetinate, is potentially for the treatment of glioblastoma. Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients. trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases. |
| CSN25802 | TCN 201 | 852918-02-6 | TCN-201 is a sulphonamide derivative that negatively modulates glycine binding to the GluN1 (glutamate receptor subunit) subunit of the receptor. |
| CSN18033 | SDZ 220-581 hydrochloride | 179411-93-9 | SDZ 220-581 HCl is a potent, competitive antagonist at the NMDA glutamate receptor subtype (pKi= 7.7). |
| CSN18034 | SDZ 220-581 Ammonium salt | 179411-94-0 | SDZ 220-581 ammonium is a potent, competitive antagonist at the NMDA glutamate receptor subtype (pKi= 7.7). |
| CSN15699 | Sarcosine | 107-97-1 | Sarcosine is an NMDAR co-agonist at the glycine binding site. It is an intermediate and byproduct in glycine synthesis and degradation. |
| CSN17681 | Ro 25-6981 Maleate | 1312991-76-6 | Ro 25-6981 maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. |
| CSN17353 | Ro 25-6981 | 169274-78-6 | Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. |
| CSN26712 | Rislenemdaz | 808732-98-1 | Rislenemdaz, also known as MK-0657, is a NR2B-selective NMDA antagonist potentially for the treatment of Parkinson's disease. |
| CSN17520 | Rapastinel | 117928-94-6 | Rapastinel is a putative NMDAR functional glycine-site partial agonist. |
| CSN23784 | Radiprodil | 496054-87-6 | Radiprodil is a selective antagonist of NMDA NR2B that used in treatment of neuropathic pain. |
| CSN16857 | QNZ46 | 1237744-13-6 | QNZ46 is a noncompetitive and voltage-independent GluN2C/GluN2D-selective NMDA antagonist with IC50 values of 3, 6, 229 μM for GluN2D, GluN2C, GluN2A, respectively. |
| CSN17346 | PEAQX | 459836-30-7 | PEAQX is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A (IC50=270 nM), rather than 1A/2B(29,600 nM). |
| CSN19272 | PEAQX tetrasodium hydrate | N/A | PEAQX is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A (IC50=270 nM), rather than 1A/2B(29,600 nM). |
| CSN11639 | Oxysophoridine | 54809-74-4 | Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L. Oxysophoridine inhibited N-methyl-D-aspartate NR1 mRNA and protein expression in the cerebral cortex of mice with cerebral ischemia/reperfusion injury. |
| CSN24186 | NMDAR antagonist 1 | 2220162-06-9 | NMDAR antagonist 1 is a NR2B-selective NMDAR antagonist. |
| CSN17347 | NMDA-IN-1 | 700878-19-9 | NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM. Its NR2B Ca2+ influx IC50 is 9.7 nM without activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. |
| CSN13790 | NMDA | 6384-92-5 | NMDA is an amino acid derived specific agonist at the NMDA receptor. |
| CSN29465 | L-Cysteinesulfinic acid | 1115-65-7 | NMDA and mGlu agonist. |
| CSN13916 | MDL 105519 | 161230-88-2 | MDL 105519 is a potent and selective inhibitor of [3H]glycine binding to the NMDA receptor with Kd of 3.89 nM. |
| CSN20030 | Lanicemine | 153322-05-5 | Lanicemine is a low-trapping NMDA receptor antagonist. Lanicemine is used the management of severe and treatment-resistant depression. Lanicemine was originally developed as a neuroprotective agent, but was redeveloped as an antidepressant. |
| CSN25807 | cis-α-(Carboxycyclopropyl)glycine | 117857-95-1 | L-CCG-IV is a potent agonist of the NMDA receptor. |
| CSN17128 | L-701324 | 142326-59-8 | L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor. |
| CSN21303 | Kynurenic acid sodium | 2439-02-3 | Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selective ligand of the GPR35 receptor. |
| CSN21125 | Ibotenic acid | 2552-55-8 | Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. |
| CSN22199 | GNE 5729 | 2026635-66-3 | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
| CSN22417 | GNE-0723 | 1883518-31-7 | GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. |
| CSN25810 | Gavestinel sodium salt | 153436-38-5 | Gavestinel is a selective antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex with Kd of 0.8 nM. |
| CSN17519 | Felbamate hydrate | 1177501-39-1 | Felbamate is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) . |
| CSN21590 | D-AP5 | 79055-68-8 | D-AP5 is an antagonist of NMDA receptor (N-methyl-D-aspartate receptor). |
| CSN18296 | CIQ | 486427-17-2 | CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. |
| CSN19842 | CGP 37849 | 127910-31-0 | CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). |
| CSN22349 | Apimostinel | 1421866-48-9 | Apimostinel is an oral NMDA receptor partial agonist. |
| CSN22086 | 7-Chlorokynurenic acid sodium salt | 1263094-00-3 | 7-Chlorokynurenic acid sodium salt is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with Ki of 0.59 μM. |
| CSN25808 | 7-Chlorokynurenic acid | 18000-24-3 | 7-Chlorokynurenic acid is an antagonist of NMDA receptor acting at the glycine site. It can also act as competitive inhibitor of L-glutamate transport into synaptic vesicles. |
| CSN24923 | 6-Methoxy-2-naphthoic acid | 2471-70-7 | 6-Methoxy-2-naphthoic acid is an modulator of NMDAR. |
| CSN25440 | 1-Aminocyclobutanecarboxylic acid | 22264-50-2 | 1-Aminocyclobutanecarboxylic acid is a NMDA receptor partial agonist acting at the glycine site, NR1. |
| CSN23429 | L-Glutamic acid | 56-86-0 | (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system. |
| CSN25118 | D-Serine | 312-84-5 | (R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. |
| CSN17580 | (-)-Dizocilpine maleate | 121917-57-5 | (-)-MK 801 maleate is the enantiomer of (+)-MK-801, which is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . |
| CSN25441 | (-)-Aspartic acid | 1783-96-6 | (-)-Aspartic acid is an endogenous NMDA receptor agonist. |
| CSN13883 | Dizocilpine maleate | 77086-22-7 | (+)-MK 801 Maleate is a highly potent, selective and non-competitive NMDA receptor antagonist with Ki of 30.5 nM. |
| CSN64512 | Quinolinic acid | 89-00-9 | |
| CSN50046 | Bis(7)-tacrine dihydrochloride | 224445-12-9 | |
| CSN102298 | 5-Chloro-7-(trifluoromethyl)quinoxaline-2,3-diol | 153504-72-4 |
