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Notch
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22137 | tCFA15 | 220757-88-0 | tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notchsignaling. |
| CSN16909 | Semagacestat | 425386-60-3 | Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM. |
| CSN27258 | SAHM1 | 2050906-89-1 | SAHM1 is a stabilized hydrocarbon-stapled alpha helical peptide targeting Notch pathway. It mimics a dominant negative form of MAML, inhibits canonical Notch transcription complex formation. |
| CSN27582 | RIN1 | 2682114-39-0 | RIN1 is a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ. It also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling. |
| CSN14398 | Medicarpin | 32383-76-9 | Medicarpin, a natural product isolated and purified from the herb of Hedysarum polybotrys Hand. Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. |
| CSN15691 | Crenigacestat | 1421438-81-4 | LY3039478 is a novel, potent Notch inhibitor with an IC50 of 0.41 nM. |
| CSN18826 | IMR-1A | 331862-41-0 | IMR-1A is the metabolite of IMR-1, a Notch inhibitor targeting the transcriptional activation. |
| CSN18825 | IMR-1 | 310456-65-6 | IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex with IC50 of 6 μM for targeting the transcriptional activation. |
| CSN18205 | FLI-06 | 313967-18-9 | FLI-06 is a Notch signaling inhibitor with EC50 of 2.3 μM which can disrupt Notch trafficking and processing. |
| CSN27670 | Limantrafin | 218457-67-1 | CB-103 is a first-in-class orally active pan-notch signaling pathway inhibitor extracted from patent US9296682B2 with anti-tumor activity. |
| CSN17939 | BMS-983970 | 1584713-87-0 | BMS-983970 is an oral pan-Notch inhibitor for the treatment of cancer. |
