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ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG), which will then induce smooth muscle relaxation. This is particularly important in the vasculature, where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of the vasculature to relax. This relaxation will decrease total peripheral resistance, which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart's having to do less work.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21949 | Brain Natriuretic Peptide | 114471-18-0 | Brain Natriuretic Peptide (1-32), Human is an endogenous peptide agonist at ANP receptor A (NPR1). |
| CSN32952 | 1-Cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide | 1394592-04-1 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Antagonists Signal Transduction Modulators |
| CSN32954 | 1-(cis-4-((6-(3-Fluorophenyl)-2-(((R)-1-hydroxypropan-2-yl)amino)quinazolin-4-yl)amino)cyclohexyl)-3-((R)-1-hydroxy-3-methylbutan-2-yl)urea | 2190508-93-9 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32968 | NPR1 Agonist 10 | 2562321-74-6 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32965 | NPR1 Agonist 7 | 2562323-16-2 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32969 | NPR1 Agonist 11 | 2562321-73-5 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32978 | NPR1 Agonist 19 | 2143955-64-8 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32959 | NPR1 Agonist 5 | 2144388-77-0 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32979 | NPR1 Agonist 20 | 2147721-31-9 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32955 | 1-(cis-4-((6-(3-Fluorophenyl)-2-(((R)-1-hydroxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-3-((R)-1-hydroxy-3-methylbutan-2-yl)urea | 2190502-77-1 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32967 | NPR1 Agonist 9 | 2562321-75-7 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32958 | NPR1 Agonist 4 | 2148282-47-5 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32953 | 1-(cis-4-((6-(3-Fluorophenyl)-2-(((R)-1-hydroxypropan-2-yl)amino)quinazolin-4-yl)amino)cyclohexyl)-3-(1-hydroxy-2-methylpropan-2-yl)urea | 2197964-77-3 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32970 | NPR1 Agonist 12 | 2562327-68-6 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN32964 | NPR1 Agonist 6 | 2562323-46-8 | Atrial Natriuretic Peptide A (NPR1; Guanylate Cyclase A) Receptor Agonists Signal Transduction Modulators |
| CSN80178 | C-Type Natriuretic Peptide (CNP) (1-22), human TFA | 1966153-17-2 |
