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Nucleoside Antimetabolite/Analog
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12234 | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | 3690-10-6 | Zebularine is a DNA methylation inhibitor which forms a covalent complex with DNA methyltransferases, it also inhibits cytidinedeaminase with Ki of 2 μM. |
| CSN23440 | 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 58-96-8 | Uridin is a nucleoside and one of main component in RNA. |
| CSN13929 | Tipiracil | 183204-74-2 | Tipiracil is a thymidine phosphorylase (TPase) inhibitor. |
| CSN17223 | 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride | 183204-72-0 | Tipiracil HCl is an inhibitor of thymidine phosphorylase (TPase) with IC50 of 35 nM. It has been used in the combination therapy of metastatic colorectal cancer. |
| CSN21983 | Trifluridine/tipiracil HCl mixture | 733030-01-8 | TAS-102 is an oral combination drug consisting of trifluridine (FTD), which is a thymidine-based nucleoside analog, and tipiracil HCl (TPI), which improves the bioavailability of FTD by inhibiting its catabolism by thymidine phosphorylase (TP). |
| CSN23840 | Sapacitabine | 151823-14-2 | Sapacitabine is an orally available nucleoside analog prodrug that is structurally related to cytarabine. |
| CSN21152 | Guadecitabine sodium | 929904-85-8 | Same as guadecitabine, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. |
| CSN16876 | RX-3117 | 865838-26-2 | RX-3117 is a cytidine analog showing anticancer activity in several cancer cell lines, including gemcitabine-resistant variants. |
| CSN13747 | (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | 1867-73-8 | N6-Methyladenosine is an abundant nucleoside in cellular mRNA that undergoes demethylation under physiological conditions by fat mass and obesity-associated protein (FTO). |
| CSN17509 | Mycophenolate mofetil hydrochloride | 116680-01-4 | Mycophenolate mofetil HCl, is an immunosuppressant drug used to prevent rejection in organ transplantation. |
| CSN18532 | LY2334737 | 892128-60-8 | LY2334737 is an orally available prodrug of gemcitabine which is a nucleoside analog used as chemotherapy. |
| CSN20570 | Guadecitabine | 929901-49-5 | Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. |
| CSN18105 | Gemcitabine elaidate | 210829-30-4 | Gemcitabine elaidate is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. |
| CSN13668 | Forodesine | 209799-67-7 | Forodesine is an orally bioavailable PNP inhibitor with picomolar potency and induces apoptosis, mainly in T cells. |
| CSN18179 | Forodesine HCl | 284490-13-7 | Forodesine HCl is an orally bioavailable PNP inhibitor with picomolar potency and induces apoptosis, mainly in T cells. |
| CSN24306 | 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | 65-46-3 | Cytidine is a non-essential aminoacid. |
| CSN10734 | 4-Amino-1-((2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride | 69-74-9 | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor. |
| CSN12531 | 5-Amino-1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one | 134-58-7 | Azaguanine-8 is a purine analog showing antineoplastic activity by competing with guanine in the metabolism. |
| CSN25514 | 6-Thioinosine | 574-25-4 | 6-Mercaptopurine-9-β-D-ribofuranoside is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2]. |
| CSN19354 | 4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one | 320-67-2 | 5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. |
