OGGs belong to the helix-hairpin-helix (HhH) superfamilly of base excision repair DNA glycosylases. OGGs are not the only enzymes able to cleave 8-oxoG from DNA. OGG members are divided into three subfamilies OGG1, OGG2 and AGOG, which correspond more or less to the three kingdoms of life. Eukaryotic OGG1 cleaves 8-oxoG only when paired with cytosine. Despite the lack of sequence homology. OGG enzymes are all described as bifunctional enzymes, which have both glycosylase and β-lyase activities in vitro.
|CSN25635||OGG1 Inhibitor O8||350997-39-6||O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG1-mediated catalysis but did not reduce DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.|