Orexin Receptor | GPCR/G Protein|Neuronal Signaling| CSNpharm

OX Receptor

OX Receptor
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货号	产品名	CAS号	信息
CSN27292	YNT 185	1804978-81-1	YNT 185 is potent and selective orexin OX2 receptor agonist with EC50 of 28 nM at human OX2 expressed in CHO cells. YNT 185 displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells).
CSN18978	TCS-OX2-29	372523-75-6	TCS-OX2-29 is a potent and selective orexin 2 (OX2) receptor antagonist with IC50 of 40 nM.
CSN16236	TCS 1102	916141-36-1	TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).
CSN16826	SB-674042	483313-22-0	SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM) exhibiting 100-fold selectivity for OX1 over OX2 receptors.
CSN20633	SB-649868	380899-24-1	SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
CSN16521	SB-408124	288150-92-5	SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, and exhibits 50-fold selectivity over OX2 receptor.