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OX Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN27292 | YNT-185 | 1804978-81-1 | YNT 185 is potent and selective orexin OX2 receptor agonist with EC50 of 28 nM at human OX2 expressed in CHO cells. YNT 185 displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). |
| CSN18978 | TCS-OX2-29 | 372523-75-6 | TCS-OX2-29 is a potent and selective orexin 2 (OX2) receptor antagonist with IC50 of 40 nM. |
| CSN16236 | TCS 1102 | 916141-36-1 | TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). |
| CSN20432 | Seltorexant | 1293281-49-8 | Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species. |
| CSN16826 | SB-674042 | 483313-22-0 | SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM) exhibiting 100-fold selectivity for OX1 over OX2 receptors. |
| CSN20633 | SB-649868 | 380899-24-1 | SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). |
| CSN16521 | SB-408124 | 288150-92-5 | SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, and exhibits 50-fold selectivity over OX2 receptor. |
| CSN17847 | SB-408124 Hydrochloride | 1431697-90-3 | SB-408124 HCl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively and exhibits 50-fold selectivity over OX2 receptor. |
| CSN11490 | SB-334867 | 249889-64-3 | SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
| CSN11489 | SB-334867 free base | 792173-99-0 | SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with pKb of 7.2. |
| CSN50652 | ORN-0829 hydrate | 1793073-93-4 | ORN-0829 is a potent dual orexin 1/2 receptor antagonist. |
| CSN18036 | Orexin 2 Receptor Agonist | 1796565-52-0 | Orexin 2 receptor agonist is a potent and selective OX2R agonist with EC50 of 23 nM. |
| CSN13779 | Filorexant | 1088991-73-4 | MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor (< 3 nM in binding). |
| CSN16552 | MK-3697 | 1224846-01-8 | MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. |
| CSN18852 | MK-1064 | 1207253-08-4 | MK-1064 is a selective orexin 2 receptor antagonist(2-SORA) for the research of insomnia. |
| CSN17756 | Lemborexant | 1369764-02-2 | Lemborexant is a dual antagonist of the orexin OX1 and OX2 receptors which is under development for treatment of insomnia. |
| CSN26720 | YNT-185 dihydrochloride | 1804978-82-2 | for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2]. |
| CSN26371 | EMPA | 680590-49-2 | EMPA is highly potent, selective OX2 receptor antagonist with IC50 values of 2.3 nM and 1900 nM for OX2 and OX1 respectively. |
| CSN17023 | Almorexant | 871224-64-5 | Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
| CSN13780 | Almorexant hydrochloride | 913358-93-7 | Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
| CSN20430 | ACT-462206 | 1361321-96-1 | ACT-462206 is a potent and brain-penetrant dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively), and it exhibits anxiolytic-like properties in vivo. |
| CSN33694 | GSK1059865 | 1191044-58-2 |
