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P-gp
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12751 | Zosuquidar 3HCl | 167465-36-3 | Zosuquidar 3HCl is the 3HCl form of Zosuquidar. Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60% at 2 and 10μM and had no effect at 0.08 and 0.4μM. |
| CSN12182 | Valspodar | 121584-18-7 | Valspodar is a P-glycoprotein (P-gp) inhibitor widely used in preclinical and clinical studies for overcoming multidrug resistance (MDR). |
| CSN14774 | Taxinine B | 18457-44-8 | Taxinine B, a natural product isolated and purified from the barks of Taxus chinensis, can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells, and shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA). |
| CSN12910 | Tariquidar | 206873-63-4 | Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM, reverses drug resistance in MDR cell Lines. |
| CSN13177 | Sinapine Thiocyanate | 7431-77-8 | Sinapine, an alkaloid isolated and purified from the seeds of Raphanus sativus L., possess antioxidant and radio-protective activities, downregulats multi-drug resistance 1 (MDR1) expression. |
| CSN22057 | Sinapine | 18696-26-9 | Sinapine is an alkaloid from seeds of the cruciferous species which shows antioxidant and radio-protective activities and decreases expression of P-glycoprotein in Caco-2 cells. |
| CSN19434 | Schizandrin | 7432-28-2 | Schizandrin is a natural product possessing antioxidant and anti-inflammatory activities. |
| CSN16588 | SC144 | 895158-95-9 | SC144 showed its function through both exhibiting potent cytotoxicity, by itself or synergism with other compounds, against a panel of drug-sensitive and drug-resistant cancer cell lines, and targeting to gp130. |
| CSN18576 | SC144 HCl | 917497-70-2 | SC144 HCl is the first-in-class orally active small-molecule gp130 inhibitor (IC50 = 0.72 μM) which blocks cytokine-triggered gp130 signaling. |
| CSN25413 | RCGD423 | 108237-91-8 | RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair. |
| CSN14118 | Phyllanthin | 10351-88-9 | Phyllanthin, a natural product isolated and purified from the herb of Phyllanthus niruri L., is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp. |
| CSN13555 | Isosinensetin | 17290-70-9 | Isosinensetin exhibits HIV-1 protease inhibiting and antioxidant activities. It is a natural product isolated and purified from the fruit of Citrus aurantium L.. |
| CSN10894 | Elacridar | 143664-11-3 | Elacridar is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. |
| CSN13175 | Elacridar HCl | 143851-98-3 | Elacridar HCl is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-gp to investigate the role of transporters in the disposition of various test molecules. |
| CSN17917 | Dofequidar Fumarate | 153653-30-6 | Dofequidar fumarate, an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both. |
| CSN22768 | CP 100356 HCl | 142715-48-8 | CP 100356 HCl is a high affinity P-glycoprotein (P-gp) inhibitor with Kis of 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms. |
