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P2X Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21352 | BzATP Triethylammonium Salt | 112898-15-4 | Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase. |
| CSN21404 | BzATP | 81790-82-1 | Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase. |
| CSN11254 | KN-62 | 127191-97-3 | KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.. |
| CSN19839 | JNJ 47965567 | 1428327-31-4 | JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). |
| CSN22409 | Gefapixant | 1015787-98-0 | Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. |
| CSN10731 | CTP Disodium Dihydrate | 81012-87-5 | CTP Disodium Dihydrate is a P2X4 purinergic receptor agonist. |
| CSN25312 | BX430 | 688309-70-8 | BX430 is selective P2X4 allosteric antagonist with IC50 of 0.54 μM. |
| CSN19020 | A-804598 | 1125758-85-1 | A-804598 is a competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
| CSN18291 | A-317491 | 475205-49-3 | A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors. |
