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p38 MAPK

p38 MAPK

货号 产品名 CAS号 信息
CSN16728 VX-745 209410-46-8 VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.
CSN21102 UM-164 903564-48-7 UM-164 is a potent dual c-Src/p38 kinase inhibitor that exhibits potent anti-TNBC activity in xenograft models. UM-164 inhibits p38 kinase and binds to an inactive c-Src conformation.
CSN26722 Talmapimod HCl 309915-12-6 Talmapimod, also known as SCIO-469, is an orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis.
CSN15958 TAK-715 303162-79-0 TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, being 28-fold selective for p38α over p38β, showing no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
CSN13149 SKF-86002 72873-74-6 SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 μM and inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).
CSN26187 Sesamolin 526-07-8 Sesamolin is a furofuran lignan extracted from sesame seeds, which has beneficial physiological properties such as antioxidant, anti-mutagenic, anti-aging and anti-inflammatory activities. It was also found to inhibit lipid peroxidation in rat liver and kidney.
CSN27555 SD-169 1670-87-7 SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation.
CSN18176 SD-06 271576-80-8 SD-06 is a p38 MAP kinase inhibitor and inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83% inhibition at 1mg/kg, po).
CSN16503 Scopoletin 92-61-5 Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-κB and p38 MAPK.
CSN18198 SCIO-469 309913-83-5 SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38α in vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
CSN13746 SB-242235 193746-75-7 SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM.
CSN11899 SB-203580     152121-47-6 SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.
CSN12267 SB-202190 152121-30-7 SB-202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also shows slightly weaker activity for BRD4 (Kd=3.4 μM).
CSN12897 SB-239063 193551-21-2 SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38α.
CSN13817 PD169316 152121-53-4 PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).
CSN17386 p38 MAPK-IN-1 1006378-90-0 p38 MAPK-IN-1 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM, shows sustained levels, low clearance and good bioavailability.
CSN14542 Neoechinulin A 51551-29-2 Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
CSN22457 MAPK13-IN-1 229002-10-2 MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM.
CSN23347 Methyl Ferulate 2309-07-1 Methyl Ferulate is a naturally-occurring phenolic with antioxidant activities and inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.
CSN22233 ITX5061 1252679-52-9 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
CSN22404 FR 167653 158876-66-5 FR-167653 is a selective p38 MAPK inhibitor.
CSN22405 FR 167653 Free Base 158876-65-4 FR-167653 is a selective p38 MAPK inhibitor.
CSN10856 Doramapimod 285983-48-4 Doramapimod is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
CSN19850 Deoxynivalenol 51481-10-8 Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor.
CSN19015 Dehydrocorydaline Chloride 10605-03-5 Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities.
CSN19908 Comuside 131189-57-6 Cornuside, a natural product isolated and purified from the fruits of Cornus officinalis Sieb.
CSN19454 Asiatic Acid 464-92-6 Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, commonly used in wound healing by increasing collagen production.
CSN24901 3,4-Dihydroxyhydrocinnamic acid 1078-61-1 3,4-Dihydroxyhydrocinnamic acid is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties.
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