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P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN23943 | SJFδ | 2254609-23-7 | SJFδ is a PROTAC selectively targeting on p38δ, consist of a warhead of foretinib linked to VHL-recruiting ligand. SJFδ exhibited DC50/Dmax values of 79.2nM/98.4% and 45.9nM/34.5% for degradation of p38δ and p38α, respectively. |
CSN23942 | SJFα | 2254609-27-1 | SJFα is a PROTAC selectively targeting on p38α, consist of a warhead of foretinib linked to VHL-recruiting ligand. |
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