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P450

P450

货号 产品名 CAS号 信息
CSN21919 Uniconazole 83657-22-1 Uniconazole inhibits CK biosynthesis by suppressing CYP735A activity in Arabidopsis. Uniconazole inhibits the biosynthesis of gibberellin (GA), and brassinosteroid (BR) and the catabolism of abscisic acid (ABA).
CSN12919 Talarozole 201410-53-9 Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
CSN19400 Ramatroban 116649-85-5 Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
CSN16475 Ozagrel 82571-53-7 Ozagrel is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
CSN16785 Ozagrel HCl 78712-43-3 Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
CSN18337 Orteronel 566939-85-3 Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits > 1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4.
CSN20411 ONO-1301 176391-41-6 ONO-1301 is a non-prostanoid prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. It is also a long-acting prostacyclin agonist loaded in PLGA microspheres prepared using different molecular weights of PLGA.
CSN25582 NVP-VID-400 174262-13-6 NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1.
CSN25221 NTP42 2055599-51-2 NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM.
CSN16614 Naringin 10236-47-2 Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
CSN16184 Naringin Dihydrochalcone 18916-17-1 Naringin dihydrochalcone is a sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.
CSN12625 Methoxsalen 298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN16342 Memantine HCl 41100-52-1 Memantine HCl, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively, is used for the treatment of Alzheimer's disease.
CSN16776 Ketoconazole 65277-42-1 Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively.
CSN13003 Itraconazole 84625-61-6 Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
CSN24909 Sparteine 492-08-0 Inhibition of human CYP2D6 expressed in Escherichia coli JM109
CSN20292 HET0016 339068-25-6 HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms.
CSN13053 Fluconazole 86386-73-4 Fluconazole, an inhibitor of CYP2C19, CYP2C9 and CYP3A4, is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
CSN23291 Flavone 525-82-6 Flavone can effect CYP (P450) activity, it's a class of flavonoids with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.
CSN22890 DMU2139 1821143-80-9 DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM.
CSN25347 Dazoxiben HCl 74226-22-5 Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
CSN17441 Dafadine-A 1065506-69-5 Dafadine-A, an analog of dafadine, is an inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans and also inhibits the mammalian ortholog of DAF-9 (CYP27A1).
CSN13101 Chlorzoxazone 95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN21322 CGS 15435 95853-92-2 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
CSN18701 Carbosulfan 55285-14-8 Carbosulfan inhibits relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers).
CSN16313 Benzbromarone 3562-84-3 Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM.
CSN17375 Baicalein 491-67-8 Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
CSN12906 Alizarin 72-48-0 Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2/10.0 and 2.7 μM respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
CSN22313 ABT 1614-12-6 ABT is a non-specific cytochrome P450 (CYP) inhibitor.
CSN12966 Abiraterone Acetate 154229-18-2 Abiraterone Acetate is a potent CYP17A1 inhibitor with IC50 of 4 nM.
CSN26155 6-Aminochrysene 2642-98-0 6-aminochrysene was a potent inducer of CYP1A1 in rat.
CSN19374 3-Cyano-7-Ethoxycoumarin 117620-77-6 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage.
CSN22146 1-Ethynylnaphthalene 15727-65-8 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.
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