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P450
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN21919 | Uniconazole | 83657-22-1 | Uniconazole inhibits CK biosynthesis by suppressing CYP735A activity in Arabidopsis. Uniconazole inhibits the biosynthesis of gibberellin (GA), and brassinosteroid (BR) and the catabolism of abscisic acid (ABA). |
CSN26275 | Tetrahydropiperine | 23434-88-0 | Tetrahydropiperine is a cyclohexyl analogue of piperine that inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM). |
CSN23249 | Stiripentol | 49763-96-4 | Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, it's also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. |
CSN19933 | Rhodionin | 85571-15-9 | Rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs. |
CSN19400 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
CSN26727 | Ozagrel Sodium | 189224-26-8 | Ozagrel Sodium, also known as KCT-0809 and Cataclot, is a thromboxane A2 synthase inhibitor used to treat cerebrovascular diseases. |
CSN25582 | NVP-VID-400 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
CSN29462 | 17-ODYA | 34450-18-5 | LTB ω-hydroxylase inhibitor. |
CSN24909 | Sparteine | 492-08-0 | Inhibition of human CYP2D6 expressed in Escherichia coli JM109 |
CSN26726 | Gemfibrozil 1-O-β-glucuronide | 91683-38-4 | Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2]. |
CSN22095 | Furafylline | 80288-49-9 | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. |
CSN29463 | 7-Ethoxyresorufin | 5725-91-7 | Fluorometric CYP450 substrate. |
CSN29461 | Methoxyresorufin | 5725-89-3 | Fluorometric CYP450 substrate. |
CSN23291 | Flavone | 525-82-6 | Flavone can effect CYP (P450) activity, it's a class of flavonoids with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc. |
CSN22890 | DMU2139 | 1821143-80-9 | DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM. |
CSN27199 | DMU2105 | 1031063-36-1 | DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™). |
CSN25347 | Dazoxiben HCl | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
CSN17441 | Dafadine-A | 1065506-69-5 | Dafadine-A, an analog of dafadine, is an inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans and also inhibits the mammalian ortholog of DAF-9 (CYP27A1). |
CSN13101 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM. |
CSN21322 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
CSN19045 | CDD3506 | 197913-15-8 | CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
CSN19044 | CDD3505 | 173865-33-3 | CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
CSN21515 | Bergaptin | 7380-40-7 | Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM. |
CSN22313 | ABT | 1614-12-6 | ABT is a non-specific cytochrome P450 (CYP) inhibitor. |
CSN26155 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
CSN19374 | 3-Cyano-7-Ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage. |
CSN19771 | 25R-Inokosterone | 19682-38-3 | 25R-Inokosterone has a role on cytochrome P450 from a hormone-resistant cell line. |
CSN22146 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. |
CSN29472 | (S)-Mephenytoin | 70989-04-7 | (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase. |