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P450
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN19400 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN16475 | Ozagrel | 82571-53-7 | Ozagrel is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. |
| CSN16785 | Ozagrel HCl | 78712-43-3 | Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
| CSN18337 | Orteronel | 566939-85-3 | Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits > 1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4. |
| CSN25582 | NVP-VID-400 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
| CSN25221 | NTP42 | 2055599-51-2 | NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM. |
| CSN16614 | Naringin | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| CSN16184 | Naringin Dihydrochalcone | 18916-17-1 | Naringin dihydrochalcone is a sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes. |
| CSN12625 | Methoxsalen | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN16342 | Memantine HCl | 41100-52-1 | Memantine HCl, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively, is used for the treatment of Alzheimer's disease. |
| CSN16776 | Ketoconazole | 65277-42-1 | Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. |
| CSN13003 | Itraconazole | 84625-61-6 | Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. |
| CSN20292 | HET0016 | 339068-25-6 | HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. |
| CSN13053 | Fluconazole | 86386-73-4 | Fluconazole, an inhibitor of CYP2C19, CYP2C9 and CYP3A4, is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. |
| CSN23291 | Flavone | 525-82-6 | Flavone can effect CYP (P450) activity, it's a class of flavonoids with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc. |
| CSN22890 | DMU2139 | 1821143-80-9 | DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM. |
| CSN25347 | Dazoxiben HCl | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
| CSN13101 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM. |
| CSN21322 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| CSN18701 | Carbosulfan | 55285-14-8 | Carbosulfan inhibits relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). |
| CSN16313 | Benzbromarone | 3562-84-3 | Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM. |
| CSN17375 | Baicalein | 491-67-8 | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. |
| CSN12906 | Alizarin | 72-48-0 | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2/10.0 and 2.7 μM respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| CSN22313 | ABT | 1614-12-6 | ABT is a non-specific cytochrome P450 (CYP) inhibitor. |
| CSN12966 | Abiraterone Acetate | 154229-18-2 | Abiraterone Acetate is a potent CYP17A1 inhibitor with IC50 of 4 nM. |
| CSN26155 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
| CSN19374 | 3-Cyano-7-Ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage. |
| CSN22146 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. |