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P450
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20409 | VT-1598 | 2089320-99-8 | VT1598 is a highly-selective, broad spectrum fungal CYP51 inhibitor, exhibiting excellent potency against yeast, dermatophyte, and mold fungal pathogens. |
| CSN21919 | Uniconazole | 83657-22-1 | Uniconazole inhibits CK biosynthesis by suppressing CYP735A activity in Arabidopsis. Uniconazole inhibits the biosynthesis of gibberellin (GA), and brassinosteroid (BR) and the catabolism of abscisic acid (ABA). |
| CSN26275 | Tetrahydropiperine | 23434-88-0 | Tetrahydropiperine is a cyclohexyl analogue of piperine that inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM). |
| CSN23249 | Stiripentol | 49763-96-4 | Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, it's also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. |
| CSN13587 | Ritonavir | 155213-67-5 | Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor. |
| CSN19933 | Rhodionin | 85571-15-9 | Rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs. |
| CSN26727 | Ozagrel sodium | 189224-26-8 | Ozagrel Sodium, also known as KCT-0809 and Cataclot, is a thromboxane A2 synthase inhibitor used to treat cerebrovascular diseases. |
| CSN10122 | Oxolamine citrate | 1949-20-8 | Oxolamine citrate is a cough suppressant, and a molecule involved in pharmacological studies including antiinflammatory agents, drugs that shift energy metabolism from mitochondrial respiration to glycolysis and effect on warfarin anticoagulant properties. It is an inhibitor of CYP2B1/2. |
| CSN25582 | SDZ285428 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
| CSN25221 | NTP42 | 2055599-51-2 | NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM. |
| CSN27390 | Mefentrifluconazole | 1417782-03-6 | Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). |
| CSN29462 | 17-ODYA | 34450-18-5 | LTB ω-hydroxylase inhibitor. |
| CSN26286 | Isosilybin | 72581-71-6 | Isosilybin is a flavonoid from milk thistle. It can inhibit CYP3A4 induction with an IC50 of 74 μM. |
| CSN24909 | (+)-Sparteine | 492-08-0 | Inhibition of human CYP2D6 expressed in Escherichia coli JM109 |
| CSN20292 | HET0016 | 339068-25-6 | HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. |
| CSN15653 | Ginsenoside C-K | 39262-14-1 | Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. |
| CSN26726 | Gemfibrozil 1-O-β-glucuronide | 91683-38-4 | Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2]. |
| CSN12256 | Galangin | 548-83-4 | Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 = 1 μM). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties. |
| CSN22095 | Furafylline | 80288-49-9 | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. |
| CSN29463 | 7-Ethoxyresorufin | 5725-91-7 | Fluorometric CYP450 substrate. |
| CSN29461 | Resorufin methyl ether | 5725-89-3 | Fluorometric CYP450 substrate. |
| CSN23291 | Flavone | 525-82-6 | Flavone can effect CYP (P450) activity, it's a class of flavonoids with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc. |
| CSN22890 | DMU2139 | 1821143-80-9 | DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM. |
| CSN27199 | DMU2105 | 1031063-36-1 | DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™). |
| CSN25347 | Dazoxiben | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
| CSN32917 | Dapaconazole | 1269726-67-1 | Dapaconazole,a CYP51 inhibitor is an antifungal drug candidate. |
| CSN13101 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM. |
| CSN21322 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| CSN32500 | CFG920 | 1260006-20-9 | CFG920 is a CYP17 inhibitor, is also an orally available inhibitor of the CYP17A1. |
| CSN26553 | Casopitant mesylate | 414910-30-8 | Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. |
| CSN26724 | BI 653048 | 1198784-72-3 | BI-653048 is a glucocorticoid agonist. |
| CSN21515 | Bergamottin | 7380-40-7 | Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM. |
| CSN22313 | 1-Aminobenzotriazole | 1614-12-6 | ABT is a non-specific cytochrome P450 (CYP) inhibitor. |
| CSN26155 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
| CSN26147 | (3-(Pyridin-3-yl)isoxazol-5-yl)methanamine | 543713-43-5 | 5-Aminomethyl-3-(pyridin-3-yl)isoxazole |
| CSN22146 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. |
| CSN29472 | (S)-Mephenytoin | 70989-04-7 | (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase. |
| CSN28668 | β-Naphthoflavone | 6051-87-2 | |
| CSN41685 | (S)-Mirtazapine | 61337-87-9 | |
| CSN37970 | Brexpiprazole S-oxide | 1191900-51-2 | |
| CSN33797 | Revexepride | 219984-49-3 | |
| CSN37149 | Rhodiosin | 86831-54-1 | |
| CSN44106 | 19-Hydroxyandrost-4-ene-3,17-dione | 510-64-5 | |
| CSN80842 | Tacrine | 321-64-2 | |
| CSN103439 | 8-(4-Chlorophenylsulfonamido)-4-(3-(pyridin-3-yl)propyl)octanoic acid | 134235-78-2 | |
| CSN103004 | 5-(Pyridin-3-ylmethyl)benzofuran-2-carboxylic acid | 85666-24-6 | |
| CSN104826 | 5,7-Dimethyl-2-(methylamino)-4-(pyridin-3-ylmethyl)benzo[d]thiazol-6-ol | 145096-30-6 | |
| CSN113703 | 6-(2-(Prop-2-yn-1-yloxy)phenyl)hexanoic acid | 206052-01-9 | |
| CSN51557 | DDMS | 206052-03-1 |
