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P450

P450

货号 产品名 CAS号 信息
CSN20409 VT-1598 2089320-99-8 VT1598 is a highly-selective, broad spectrum fungal CYP51 inhibitor, exhibiting excellent potency against yeast, dermatophyte, and mold fungal pathogens.
CSN21919 Uniconazole 83657-22-1 Uniconazole inhibits CK biosynthesis by suppressing CYP735A activity in Arabidopsis. Uniconazole inhibits the biosynthesis of gibberellin (GA), and brassinosteroid (BR) and the catabolism of abscisic acid (ABA).
CSN26275 Tetrahydropiperine 23434-88-0 Tetrahydropiperine is a cyclohexyl analogue of piperine that inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM).
CSN23249 1-(Benzo[d][1,3]dioxol-5-yl)-4,4-dimethylpent-1-en-3-ol 49763-96-4 Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, it's also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor.
CSN13587 Thiazol-5-ylmethyl ((2S,3S,5S)-3-hydroxy-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl)carbamate   155213-67-5 Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor.
CSN19933 Rhodionin 85571-15-9 Rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs.
CSN26727 Ozagrel sodium 189224-26-8 Ozagrel Sodium, also known as KCT-0809 and Cataclot, is a thromboxane A2 synthase inhibitor used to treat cerebrovascular diseases.
CSN10122 Oxolamine citrate 1949-20-8 Oxolamine citrate is a cough suppressant, and a molecule involved in pharmacological studies including antiinflammatory agents, drugs that shift energy metabolism from mitochondrial respiration to glycolysis and effect on warfarin anticoagulant properties. It is an inhibitor of CYP2B1/2.
CSN25582 SDZ285428 174262-13-6 NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1.
CSN25221 NTP42 2055599-51-2 NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM.
CSN27390 Mefentrifluconazole 1417782-03-6 Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM).
CSN29462 17-ODYA 34450-18-5 LTB ω-hydroxylase inhibitor.
CSN26286 Isosilybin 72581-71-6 Isosilybin is a flavonoid from milk thistle. It can inhibit CYP3A4 induction with an IC50 of 74 μM.
CSN24909 (7R,7aR,14R,14aS)-Dodecahydro-2H,6H-7,14-methanodipyrido[1,2-a:1',2'-e][1,5]diazocine 492-08-0 Inhibition of human CYP2D6 expressed in Escherichia coli JM109
CSN20292 HET0016 339068-25-6 HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms.
CSN15653 Ginsenoside C-K 39262-14-1 Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A.
CSN26726 Gemfibrozil 1-O-β-glucuronide 91683-38-4 Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2].
CSN12256 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one 548-83-4 Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 = 1 μM). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties.
CSN22095 Furafylline 80288-49-9 Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM.
CSN29463 7-Ethoxyresorufin 5725-91-7 Fluorometric CYP450 substrate.
CSN29461 Resorufin methyl ether 5725-89-3 Fluorometric CYP450 substrate.
CSN23291 2-Phenyl-4H-chromen-4-one 525-82-6 Flavone can effect CYP (P450) activity, it's a class of flavonoids with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.
CSN22890 (E)-1-(6-Methoxynaphthalen-2-yl)-3-(pyridin-3-yl)prop-2-en-1-one 1821143-80-9 DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM.
CSN27199 3-(Naphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one 1031063-36-1 DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™).
CSN25347 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride 74226-22-5 Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
CSN32917 Dapaconazole 1269726-67-1 Dapaconazole,a CYP51 inhibitor is an antifungal drug candidate.
CSN13101 Chlorzoxazone 95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN21322 Cgs 15435 95853-92-2 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
CSN32500 CFG920 1260006-20-9 CFG920 is a CYP17 inhibitor, is also an orally available inhibitor of the CYP17A1.
CSN26553 Casopitant mesylate 414910-30-8 Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.
CSN26724 BI 653048 1198784-72-3 BI-653048 is a glucocorticoid agonist.
CSN21515 Bergamottin 7380-40-7 Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM.
CSN22313 1H-Benzo[d][1,2,3]triazol-1-amine 1614-12-6 ABT is a non-specific cytochrome P450 (CYP) inhibitor.
CSN26155 6-Aminochrysene 2642-98-0 6-aminochrysene was a potent inducer of CYP1A1 in rat.
CSN26147 (3-(Pyridin-3-yl)isoxazol-5-yl)methanamine 543713-43-5 5-Aminomethyl-3-(pyridin-3-yl)isoxazole
CSN22146 1-Ethynylnaphthalene 15727-65-8 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.
CSN29472 (S)-Mephenytoin 70989-04-7 (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase.
CSN28668 β-Naphthoflavone 6051-87-2
CSN41685 (S)-Mirtazapine 61337-87-9
CSN37970 Brexpiprazole S-oxide 1191900-51-2
CSN33797 Revexepride 219984-49-3
CSN37149 Rhodiosin 86831-54-1
CSN44106 19-Hydroxyandrost-4-ene-3,17-dione 510-64-5
CSN80842 Tacrine 321-64-2
CSN103439 CGS 22652 134235-78-2
CSN103004 Furegrelate 85666-24-6
CSN104826 E 3040 145096-30-6
CSN113703 PPOH 206052-01-9
CSN51557 DDMS 206052-03-1
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