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P450
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17762 | Seviteronel racemate | 1375603-36-3 | VT-464 racemate is the racemate form of VT-464, which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM)inhibition. |
| CSN19052 | Seviteronel (R enantiomer) | 1375603-38-5 | VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464, which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM). |
| CSN17949 | Seviteronel | 1610537-15-9 | VT-464 is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. |
| CSN12213 | Voriconazole | 137234-62-9 | Voriconazole is a second-generation triazole antifungal used to treat serious fungal infections by inhibiting the synthesis of ergosterol, the major sterol of the fungal cell membrane. |
| CSN12100 | TMS | 24144-92-1 | TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). |
| CSN19048 | Talarozole (R enantiomer) | 870093-23-5 | Talarozole R-enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN12919 | Talarozole | 201410-53-9 | Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN12728 | Tak-700 | 426219-18-3 | TAK-700 is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits > 1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). |
| CSN11915 | 7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid | 112665-43-7 | Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist. |
| CSN11894 | Saperconazole | 110588-57-3 | Saperconazole is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L. |
| CSN19400 | (R)-3-(3-(4-Fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN11771 | Proadifen HCl | 62-68-0 | Proadifen HCl is a nonspecific cytochrome P450 inhibitor, it's also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 μM in mouse skeletal muscle. |
| CSN11753 | 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one | 171228-49-2 | Posaconazole is a broad-spectrum triazole antifungi, it inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme, which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins. |
| CSN19175 | CYP3cide | 1390637-82-7 | PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits > 500-fold selectivity over CYP3A5 and CYP3A7. |
| CSN11643 | Ozagrel sodium | 130952-46-4 | Ozagrel sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. |
| CSN16475 | Ozagrel | 82571-53-7 | Ozagrel is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. |
| CSN16785 | (E)-3-(4-((1H-Imidazol-1-yl)methyl)phenyl)acrylic acid hydrochloride | 78712-43-3 | Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
| CSN20004 | Oteseconazole | 1340593-59-0 | Oteseconazole is a tetrazole antifungal agent potentially for the treatment of candidal vaginal infection by inhibiting sterol 14α-demethylase (CYP51). |
| CSN18337 | Orteronel | 566939-85-3 | Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits > 1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4. |
| CSN16614 | (S)-7-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| CSN16184 | Naringin dihydrochalcone | 18916-17-1 | Naringin dihydrochalcone is a sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes. |
| CSN11433 | 2-Methyl-1,2-di(pyridin-3-yl)propan-1-one | 54-36-4 | Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. |
| CSN12625 | 9-Methoxy-7H-furo[3,2-g]chromen-7-one | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN16342 | 3,5-Dimethyladamantan-1-amine hydrochloride | 41100-52-1 | Memantine HCl, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively, is used for the treatment of Alzheimer's disease. |
| CSN16776 | Ketoconazole | 65277-42-1 | Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. |
| CSN13003 | Itraconazole | 84625-61-6 | Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. |
| CSN11218 | Isbogrel | 89667-40-3 | Isbogrel, a ω-pyridylalkenoic acid derivative, is a thromboxane A2 synthetase inhibitor that also shows thromboxane A2 antagonism. |
| CSN12387 | Galeterone | 851983-85-2 | Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. |
| CSN13053 | Fluconazole | 86386-73-4 | Fluconazole, an inhibitor of CYP2C19, CYP2C9 and CYP3A4, is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. |
| CSN10150 | FICZ | 172922-91-7 | FICZ is a tryptophan-derived, high affinity Ah receptor ligand and an efficient inducer of CYP1A1 gene expression in short time incubation (0.5 h) experiments. It is also a potent aryl hydrocarbon receptor (AHR) agonist, and also has the qualities of a perfect substrate for mammalian CYP1 enzymes. |
| CSN10830 | Diosmetin | 520-34-3 | Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants, and is an agonist of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. |
| CSN17441 | Dafadine-A | 1065506-69-5 | Dafadine-A, an analog of dafadine, is an inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans and also inhibits the mammalian ortholog of DAF-9 (CYP27A1). |
| CSN20275 | CYP11B1-IN-25 | 2101952-78-5 | CYP11B1 inhibitor C25 is a CYP11B1 inhibitor of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushing’s disease. |
| CSN15806 | Cobicistat | 1004316-88-4 | Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| CSN10660 | Clarithromycin | 81103-11-9 | Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor. |
| CSN19045 | CDD3506 | 197913-15-8 | CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
| CSN19044 | CDD3505 | 173865-33-3 | CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
| CSN10419 | Bergaptol | 486-60-2 | Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM. |
| CSN16313 | (3,5-Dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone | 3562-84-3 | Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM. |
| CSN17375 | 5,6,7-Trihydroxy-2-phenyl-4H-chromen-4-one | 491-67-8 | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. |
| CSN10357 | Avasimibe | 166518-60-1 | Avasimibe is an ACAT inhibitor with IC50 of 3.3 μM, it also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9/13.9 and 26.5 μM, respectively. |
| CSN12255 | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 520-36-5 | Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM, it's a natural product isolated and purified from the root of Scutellaria indica L.. |
| CSN12906 | 1,2-Dihydroxy-9,10-anthracenedione | 72-48-0 | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2/10.0 and 2.7 μM respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| CSN12322 | (3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | 154229-19-3 | Abiraterone is a potent CYP17A1 inhibitor with IC50 of 4 nM. |
| CSN12966 | Abiraterone Acetate | 154229-18-2 | Abiraterone Acetate is a potent CYP17A1 inhibitor with IC50 of 4 nM. |
| CSN10264 | Alpha-Naphthoflavone | 604-59-1 | 7,8-benzoflavone is a natural product isolated and purified from Passiflora, and it binds to human cytochrome P450 3A4 reveals complex fluorescence quenching. |
| CSN19374 | 3-Cyano-7-ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage. |
| CSN19771 | 25R-Inokosterone | 19682-38-3 | 25R-Inokosterone has a role on cytochrome P450 from a hormone-resistant cell line. |
