Protease-Activated Receptors | GPCR/G Protein| CSNpharm

PAR

PAR
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货号	产品名	CAS号	信息
CSN17809	TRAP-6	141136-83-6	TRAP-6 is protease-activated receptor 1 (PAR1) agonist.
CSN13679	ML161	423735-93-7	ML-161 is an allosteric and reversible inhibitor of proteinase-activated receptor 1 (PAR1) with IC50 of 0.26 μM.
CSN22353	AZ3451	2100284-59-9	AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
CSN24081	E5555	751475-53-3	Atopaxar, also known as E5555, is a potent and orally-active PAR-1 inhibitor. E5555 inhibited the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with a half maximal inhibitory concentration (IC(50)) value of 0.019μM. E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.064 and 0.031μM, respectively. E5555 showed potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.13 and 0.097μM, respectively. E5555 could be a therapeutic option for atherothrombotic disease.
CSN18572	AC-55541	916170-19-9	AC-55541 is a small-molecule protease-activated receptor 2 (PAR2) agonist and activates PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.