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PAR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN13782 | Vorapaxar | 618385-01-6 | Vorapaxar is a thrombin receptor (protease-activated receptor, PAR-1) antagonist. |
| CSN17809 | TRAP-6 | 141136-83-6 | TRAP-6 is protease-activated receptor 1 (PAR1) agonist. |
| CSN23082 | RWJ-56110 | 252889-88-6 | RWJ-56110 is a selective protease-activated receptor-1 (PAR1) antagonist. It blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. |
| CSN23119 | Protease-Activated Receptor-2, amide | 190383-13-2 | Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. |
| CSN23110 | SCH79797 dihydrochloride | 1216720-69-2 | Potent, selective non-peptide PAR1 antagonist |
| CSN13679 | Parmodulin 2 | 423735-93-7 | ML-161 is an allosteric and reversible inhibitor of proteinase-activated receptor 1 (PAR1) with IC50 of 0.26 μM. |
| CSN24477 | I-191 | 1690172-25-8 | I-191 inhibited PAR2 binding of and activation by structurally distinct PAR2 agonists (trypsin, peptide, nonpeptide) at nanomolar concentrations. |
| CSN25350 | GB-88 | 1416435-96-5 | GB-88 is an oral, selective non-peptide antagonist of PAR2. It inhibits PAR2 activated Ca2+ release with an IC50 of 2 µM. |
| CSN22824 | FSLLRY-NH2 | 245329-02-6 | FSLLRY-NH2 is a selective PAR2 peptide antagonist. |
| CSN22822 | FR-171113 | 173904-50-2 | FR 171113 is a protease-activated receptor 1 (PAR1) antagonist. |
| CSN24830 | ENMD-1068 | 789488-77-3 | ENMD-1068 is a PAR2 antagonist with IC50 value of 1.2 mM. |
| CSN22353 | AZ3451 | 2100284-59-9 | AZ3451 is a protease-activated receptor-2 (PAR2) antagonist. |
| CSN24081 | Atopaxar | 751475-53-3 | Atopaxar, also known as E5555, is a potent and orally-active PAR-1 inhibitor. E5555 inhibited the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with a half maximal inhibitory concentration (IC(50)) value of 0.019μM. E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.064 and 0.031μM, respectively. E5555 showed potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.13 and 0.097μM, respectively. E5555 could be a therapeutic option for atherothrombotic disease. |
| CSN18572 | AC-55541 | 916170-19-9 | AC-55541 is a small-molecule protease-activated receptor 2 (PAR2) agonist and activates PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. |
| CSN22664 | AC-264613 | 1051487-82-1 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist with pEC50 = 7.5. |
| CSN22646 | 2-Furoyl-LIGRLO-amide | 729589-58-6 | 2-Furoyl-LIGRLO-amide is a potent and selective PAR2 receptor agonist with pD2 of 7.0. |
