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PAR

PAR

货号 产品名 CAS号 信息
CSN17809 TRAP-6 141136-83-6 TRAP-6 is protease-activated receptor 1 (PAR1) agonist.
CSN13679 ML161 423735-93-7 ML-161 is an allosteric and reversible inhibitor of proteinase-activated receptor 1 (PAR1) with IC50 of 0.26 μM.
CSN22353 AZ3451 2100284-59-9 AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
CSN24081 E5555 751475-53-3 Atopaxar, also known as E5555, is a potent and orally-active PAR-1 inhibitor. E5555 inhibited the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with a half maximal inhibitory concentration (IC(50)) value of 0.019μM. E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.064 and 0.031μM, respectively. E5555 showed potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.13 and 0.097μM, respectively. E5555 could be a therapeutic option for atherothrombotic disease.
CSN18572 AC-55541 916170-19-9 AC-55541 is a small-molecule protease-activated receptor 2 (PAR2) agonist and activates PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.
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