Polybromo encodes a subunit of Polybromo-associated Brahma complex (PBAP). Its main biological role is involved in chromatin remodeling together with Brahma complex. It can also regulate gene transcription through DNA binding, which is dependent or independent ofthe PBAP complex.
|CSN26443||ACBI1||2375564-55-7||ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.|