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PDK is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17521 | PS-48 | 1180676-32-7 | PS48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator with Kd value of 10.3 μM and binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. |
| CSN33232 | PS210 | 1221962-86-2 | PS-210 is a selective activator of PDK1 activator. It acts by binding to the PIF-pocket allosteric docking site. |
| CSN26736 | PDK4-IN-1 | 2310262-10-1 | PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity[1]. |
| CSN17379 | MP7 | 1001409-50-2 | PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent. |
| CSN25617 | PDK4-IN-1 hydrochloride | 2310262-11-2 | PDK-4 Inhibitor compound 8c HCl is an allosteric PDK-4 inhibitor with IC50 value of 84nM. |
| CSN12988 | OSU-03012 (AR-12) | 742112-33-0 | OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
| CSN27211 | JX06 | 729-46-4 | JX06 is a selective covalent PDK1 inhibitor with IC50 values of 49, 101 and 313nM for PDK-1, PDK-2 and PDK-3, respectively. |
| CSN17589 | GSK2334470 | 1227911-45-6 | GSK2334470 is a PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases. |
| CSN12711 | BX795 | 702675-74-9 | BX795 is a potent and selective dual inhibitor of TBK1/PDK1 with IC50s of 2 nM/6 nM respectively, also inhibit Aurora B and IκB kinase ε (IKKε). |
| CSN19146 | BX517 | 850717-64-5 | BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM. |
| CSN17175 | BX-912 | 702674-56-4 | BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM, showing > 10 fold selectivity over PKA, PKC, C-Kit, EGFR etc. |
