PDK

PDK is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.

PDK
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货号	产品名	CAS号	信息
CSN17521	PS48	1180676-32-7	PS48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator with Kd value of 10.3 μM and binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
CSN26736	PDK4-IN-1	2310262-10-1	PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity[1].
CSN25617	PDK-4 Inhibitor compound 8c HCl	2310262-11-2	PDK-4 Inhibitor compound 8c HCl is an allosteric PDK-4 inhibitor with IC50 value of 84nM.
CSN27211	JX06	729-46-4	JX06 is a selective covalent PDK1 inhibitor with IC50 values of 49, 101 and 313nM for PDK-1, PDK-2 and PDK-3, respectively.
CSN17589	GSK2334470	1227911-45-6	GSK2334470 is a PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.
CSN19146	BX517	850717-64-5	BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.