PDK is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.
|CSN17521||PS48||1180676-32-7||PS48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator with Kd value of 10.3 μM and binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.|
|CSN26736||PDK4-IN-1||2310262-10-1||PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity.|
|CSN25617||PDK-4 Inhibitor compound 8c HCl||2310262-11-2||PDK-4 Inhibitor compound 8c HCl is an allosteric PDK-4 inhibitor with IC50 value of 84nM.|
|CSN27211||JX06||729-46-4||JX06 is a selective covalent PDK1 inhibitor with IC50 values of 49, 101 and 313nM for PDK-1, PDK-2 and PDK-3, respectively.|
|CSN17589||GSK2334470||1227911-45-6||GSK2334470 is a PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.|
|CSN19146||BX517||850717-64-5||BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.|