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PGE synthesis (prostaglandin E synthase, PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.

PG Synthase

货号 产品名 CAS号 信息
CSN12248 Zomepirac sodium salt 64092-48-4 Zomepirac sodium is a pyrrole-acetic acid structurally related to tolmetin sodium and a prostaglandin synthetase inhibitor.
CSN12019 Suprofen 40828-46-4 Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN16384 Pranoprofen 52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN32919 Pizuglanstat 1244967-98-3 Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor.
CSN18534 MF63 892549-43-8 MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.
CSN21241 KW-8232 free base 170365-25-0 KW-8232 free base is an anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
CSN26338 HQL-79 162641-16-9 HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase, one of two synthases involved in the production of prostaglandin D2 (PGD2) from arachidonic acid.
CSN17603 hPGDS-IN-1 1234708-04-3 hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.
CSN12831 HPGDS inhibitor 1 1033836-12-2 HPGDS inhibitor 1 is a selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
CSN24192 HPGDS inhibitor 2 2101626-26-8 GSK-2894631A is a highly potent and selective HPGDS inhibitor with IC50 value of 9.9nM.
CSN11044 2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid 5104-49-4 Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
CSN10466 Bismuth Subsalicylate 14882-18-9 Bismuth subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
CSN27768 AT-56   162640-98-4 AT 56 is an orally active L-PGDS inhibitor with IC50 value of 95μM. It inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.
CSN38729 PGS-IN-1 102271-49-8
CSN75978 YS121 916482-17-2
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