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PGE synthesis (prostaglandin E synthase, PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12248 | Zomepirac Sodium | 64092-48-4 | Zomepirac sodium is a pyrrole-acetic acid structurally related to tolmetin sodium and a prostaglandin synthetase inhibitor. |
| CSN12019 | Suprofen | 40828-46-4 | Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID). |
| CSN16384 | Pranoprofen | 52549-17-4 | Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology. |
| CSN12831 | HPGDS Inhibitor 1 | 1033836-12-2 | HPGDS inhibitor 1 is a selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM. |
| CSN11044 | Flurbiprofen | 5104-49-4 | Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. |
| CSN10466 | Bismuth Subsalicylate | 14882-18-9 | Bismuth subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2. |
