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PIKfyve
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN15968 | YM-201636 | 371942-69-7 | YM-201636 is a selective PIKfyve inhibitor with IC50 of 33 nM. |
| CSN27620 | Vacuolin-1 | 351986-85-1 | Vacuolin-1 is cell-permeable inhibitor of lysosomal exocytosis and can block the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. Vacuolin-1 is also PIKfyve inhibitor that inhibits late-stage autophagy by impairing lysosomal maturation. |
| CSN16251 | Psoralidin | 18642-23-4 | Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation. |
| CSN16316 | APY0201 | 1232221-74-7 | APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. It is a unique small molecular IL-12/23 production inhibitor. |
| CSN16991 | Apilimod mesylate | 870087-36-8 | Apilimod mesylate is a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines. |
| CSN10321 | Apilimod | 541550-19-0 | Apilimod is a PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines. |
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