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PIKfyve
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN16316 | APY0201 | 1232221-74-7 | APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. It is a unique small molecular IL-12/23 production inhibitor. |
CSN16991 | Apilimod Mesylate | 870087-36-8 | Apilimod mesylate is a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines. |
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