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PKA

PKA

货号 产品名 CAS号 信息
CSN14293 Warangalone 4449-55-2 Warangalone is a powerful inhibitor of protein kinase A isolated and purfied from the stem bark of Erythrina addisoniae, shows marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.
CSN26523 Verosudil 1414854-42-4 Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.
CSN27259 STAD 2 1542100-77-5 STAD 2 is a PKA-tageting hydrocarbon stapled peptides. It is derived from the A Kinase Binding (AKB) domain of several AKAPs and was chemically modified to contain an all-hydrocarbon staple. Thus, it selectively binds PKA-RII and disrupt AKAP-mediated PKA signaling in cells.
CSN23047 PKI(5-24) 99534-03-9 PKI (5-24) is a high affinity PKA inhibitor with Ki of 2.3 nM.
CSN26193 KT5823 126643-37-6 KT 5823 is a selective inhibitor of the cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
CSN26206 KT5720 108068-98-0 KT 5720 is a potent, specific and cell-permeable inhibitor of PKA,with a Ki of 60 nM.
CSN27678 HA-100 dihydrochloride 210297-47-5 HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 µM, respectively).
CSN26207 HA-100 84468-24-6 HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase (IC50 values are 4, 8, 12 and 240 μM, respectively).
CSN11132 H-89 127243-85-0 H 89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM showing weak inhibition on PKG, PKC, CK1, CK2 and others kinases.
CSN19160 H-89 dihydrochloride   130964-39-5 H 89 2HCl is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM. It also shows weak inhibition on PKG, PKC, CK1, CK2 and others kinases.
CSN22551 GSK180736A 817194-38-0 GSK180736A is an inhibitor of G protein-coupled receptor kinase 2 (GRK2) with IC50 of 0.77 μM.
CSN10984 Fasudil Hydrochloride 105628-07-7 Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
CSN10499 Bucladesine sodium 16980-89-5 Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation.
CSN10745 Daphnetin 486-35-1 Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM respectively. It derives from plants of the genus Daphne.
CSN22783 Cw 008 1134613-19-6 CW 008 is a PKA signaling activator.
CSN18609 Bucladesine calcium 938448-87-4 Bucladesine Calcium is a cell-permeable PKA activator that functions by preferentially activating endogenous cAMP.
CSN13758 AT13148 1056901-62-2 AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
CSN10180 8-Bromo-cAMP sodium salt 76939-46-3 8-Bromo-cAMP is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM and a PKA activator.
CSN81136 H-9 Dihydrochloride 116700-36-8
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