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PKA
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN14293 | Warangalone | 4449-55-2 | Warangalone is a powerful inhibitor of protein kinase A isolated and purfied from the stem bark of Erythrina addisoniae, shows marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively. |
| CSN26523 | Verosudil | 1414854-42-4 | Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG. |
| CSN27259 | STAD 2 | 1542100-77-5 | STAD 2 is a PKA-tageting hydrocarbon stapled peptides. It is derived from the A Kinase Binding (AKB) domain of several AKAPs and was chemically modified to contain an all-hydrocarbon staple. Thus, it selectively binds PKA-RII and disrupt AKAP-mediated PKA signaling in cells. |
| CSN23047 | PKI(5-24) | 99534-03-9 | PKI (5-24) is a high affinity PKA inhibitor with Ki of 2.3 nM. |
| CSN26193 | KT5823 | 126643-37-6 | KT 5823 is a selective inhibitor of the cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM. |
| CSN26206 | KT5720 | 108068-98-0 | KT 5720 is a potent, specific and cell-permeable inhibitor of PKA,with a Ki of 60 nM. |
| CSN27678 | HA-100 2HCl | 210297-47-5 | HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 µM, respectively). |
| CSN26207 | HA-100 | 84468-24-6 | HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase (IC50 values are 4, 8, 12 and 240 μM, respectively). |
| CSN11132 | H-89 | 127243-85-0 | H 89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM showing weak inhibition on PKG, PKC, CK1, CK2 and others kinases. |
| CSN19160 | H-89 2HCl | 130964-39-5 | H 89 2HCl is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM. It also shows weak inhibition on PKG, PKC, CK1, CK2 and others kinases. |
| CSN22551 | GSK180736A | 817194-38-0 | GSK180736A is an inhibitor of G protein-coupled receptor kinase 2 (GRK2) with IC50 of 0.77 μM. |
| CSN10984 | 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride | 105628-07-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN10499 | Sodium (4aR,6R,7R,7aR)-6-(6-butyramido-9H-purin-9-yl)-7-(butyryloxy)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide | 16980-89-5 | Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. |
| CSN10745 | 7,8-Dihydroxy-2H-chromen-2-one | 486-35-1 | Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM respectively. It derives from plants of the genus Daphne. |
| CSN22783 | CW 008 | 1134613-19-6 | CW 008 is a PKA signaling activator. |
| CSN18609 | Bucladesine calcium | 938448-87-4 | Bucladesine Calcium is a cell-permeable PKA activator that functions by preferentially activating endogenous cAMP. |
| CSN13758 | AT13148 | 1056901-62-2 | AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. |
| CSN10180 | 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt | 76939-46-3 | 8-Bromo-cAMP is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM and a PKA activator. |
| CSN81136 | H-9 2HCl | 116700-36-8 |
