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PKC

PKC

货号 产品名 CAS号 信息
CSN23775 VTX-27 1321924-70-2 VTX-27 is an inhibitor of protein kinase C θ (PKC θ) and PKC δ with Kis of 0.08 nM and 16 nM, respectively.
CSN26523 Verosudil 1414854-42-4 Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.
CSN23871 UCN-01 112953-11-4 UCN-01 is a selective inhibitor of protein kinase C.
CSN21991 TPPB 497259-23-1 TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with Ki of 11.9 nM.
CSN18071 TAS-301 193620-69-8 TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.
CSN23069 Ro 32-0432 151342-35-7 Ro 32-0432 is a selective and orally active inhibitor of protein kinase C prevents T-cell activation. It displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Ro 32-0432 is orally available and prevents T cell chronic inflammation in vivo. ).
CSN17625 Ro 31-8220 125314-64-9 Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively.
CSN26383 R 59-022 93076-89-2 R 59-022 is a diacylglycerol kinase inhibitor with IC50 of 2.8 μM. R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4].
CSN24744 PKC-theta inhibitor 736048-65-0 Protein kinase C theta (PKCθ) is a serine/threonine kinase that belongs to the calcium-independent protein kinase C family. It is a key enzyme in T cell activation, differentiation and survival.
CSN23052 Prostratin 60857-08-1 Prostratin is a PKC and NF-κB activator.
CSN23246 Ro 32-0432 hydrochloride 1781828-85-0 Potent, orally active PKC inhibitor
CSN25616 PKCβ inhibitor 1 257879-35-9 PKCβ Inhibitor is a potent, reversible and ATP-competitive PKCβ inhibitor with IC50 values of 5nM and 21nM for PKCβII and βI, respectively.
CSN27692 PKC-iota inhibitor 1 2328094-11-5 PKC-iota inhibitor 1 PKC-ι ℩ inhibitor with IC50 value of 0.34μM.
CSN26392 Phorbol 12,13-dibutyrate 37558-16-0 Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter[1][2].
CSN13863 Phellopterin 2543-94-4 Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
CSN26933 O-Desmethyl Midostaurin 740816-86-8 O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
CSN18323 (Rac)-NSC305787 hydrochloride 53868-26-1 NSC305787 HCl is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.
CSN16767 Miltefosine 58066-85-6 Miltefosine is a mult-target inhibitor which can inhibit Akt, PI3K and PKC.
CSN20625 Darovasertib 1874276-76-2 LXS196 is a potent and orally active protein kinase C (PKC) inhibitor used for the treatment of uveal melanoma.
CSN26193 KT5823 126643-37-6 KT 5823 is a selective inhibitor of the cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
CSN21408 Delcasertib 949100-39-4 KAI-9803 is a potent and selective δ protein kinase C (δ PKC) inhibitor.
CSN26395 K-252c 85753-43-1 K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase, with IC50 values of 8, 8 and 10 μM respectively[1][2][3].
CSN19714 Juglone 481-39-0 Juglone significantly inhibits the proliferation and induce the apoptosis of SiHa cells and Caski cells, stimulates suicidal erythrocyte death or eryptosis at least in part by upregulation of ceramide abundance, energy depletion and activation of PKC, and prevents high-fat diet-induced liver injury and nerve inflammation in mice through inhibition of inflammatory cytokine secretion, NF-kappa B activation and endotoxin production. It's a natural product isolated and purified from the barks of Juglans regia L..
CSN14537 Isojacareubin 50597-93-8 Isojacareubin, a natural product isolated and purified from the roots of Garcinia fusca Pierre., is a potent inhibitor of protein kinase C (PKC), suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo, thus, it as a promising lead compound for the development of antihepatoma agents, and displays potent activity against H.
CSN16020 Ingenol Mebutate 75567-37-2 Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
CSN11206 Ingenol 30220-46-3 Ingenol is a diterpenoid with unique architecture and has derivatives possessing important anticancer activity.
CSN27678 HA-100 dihydrochloride 210297-47-5 HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 µM, respectively).
CSN26207 HA-100 84468-24-6 HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase (IC50 values are 4, 8, 12 and 240 μM, respectively).
CSN19160 H-89 dihydrochloride   130964-39-5 H 89 2HCl is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM. It also shows weak inhibition on PKG, PKC, CK1, CK2 and others kinases.
CSN22823 DCP-LA 28399-31-7 FR 236924 is a selective PKCε activator.
CSN10984 Fasudil Hydrochloride 105628-07-7 Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
CSN10772 Dequalinium Chloride 522-51-0 Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.
CSN21985 Decursinol angelate 130848-06-5 Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB.
CSN10745 Daphnetin 486-35-1 Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM respectively. It derives from plants of the genus Daphne.
CSN26161 D-erythro-Sphingosine 123-78-4 D-Sphingosine inhibits protein kinase C.
CSN26558 CRT0066854 hydrochloride 2250019-91-9 CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].
CSN19868 Chelerythrine 34316-15-9 Chelerythrine, a natural product isolated and purified from the herbs of Chelidonium majus with potent antimanic, antiproliferatvie and antitumor effect, can inhibit telomerase activity, and is a well-known protein kinase C inhibitor.
CSN17986 CGP60474 164658-13-3 CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP.
CSN22738 Calphostin C 121263-19-2 Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain with IC50 of 50 nM.
CSN23664 HA-100 hydrochloride 141543-63-7 C-1 HCl is a Protein kinase C and cyclic nucleotide dependent protein kinase inhibitor.
CSN20021 Bryostatin 1 83314-01-6 Bryostatin 1 is a Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM).
CSN24270 Bisindolylmaleimide X hydrochloride 145317-11-9 Bisindolylmaleimide xHCl is a potent protein kinase C (PKC) inhibitor.
CSN26742 Bisindolylmaleimide VIII acetate 138516-31-1 Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[2].
CSN25331 Bisindolylmaleimide IV 119139-23-0 Bisindolylmaleimide IV is an inhibitor of protein kinase C.
CSN22715 Bisindolylmaleimide II 137592-45-1 Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor with IC50 of 0.01 μM, and also a potent nAChR antagonist.
CSN64509 (±)-1,2-Diolein 2442-61-7
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