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PKC
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN16722 | Zoledronic acid monohydrate | 165800-06-6 | Zoledronic acid is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. |
| CSN11980 | Staurosporine | 62996-74-1 | Staurosporine is a prototypical potent ATP-competitive multikinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| CSN17145 | Sotrastaurin | 425637-18-9 | Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM and inactive to PKCζ. |
| CSN11854 | Ro 31-8220 mesylate | 138489-18-6 | Ro 31-8220 mesylate is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively. |
| CSN15884 | N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide | 120685-11-2 | PKC412 is a broad spectrum protein kinase inhibitor and inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. |
| CSN17423 | PKC-IN-1 | 1046787-18-1 | PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM. |
| CSN11701 | Phorbol 12-myristate 13-acetate | 16561-29-8 | Phorbol 12-myristate 13-acetate is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| CSN11485 | Myricetrin | 17912-87-7 | Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects. |
| CSN12991 | Ruboxistaurin HCl | 169939-93-9 | LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. |
| CSN16527 | Go 6983 | 133053-19-7 | Go6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively and less potent to PKCζ and inactive to PKCμ. |
| CSN16571 | Go6976 | 136194-77-9 | Gö6976 is a pan inhibitor of Ca2+-dependent PKC isozymes, PKCα and PKCβ1, with IC50 values of 2.3nM and 6.2nM, respectively, but has no effect on Ca2+-independent PKC isozymes PKCδ, ε and ζ. |
| CSN10464 | Bisindolylmaleimide I | 133052-90-1 | GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
| CSN12444 | 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 170364-57-5 | Enzastaurin is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. |
| CSN10607 | 1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride | 3895-92-9 | Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) and competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. |
| CSN11220 | Acteoside | 61276-17-3 | Acteoside, is a natural product isolated and purified from the herbs of Cistanche deserticola Y.C. Ma with known antioxidant activity. It is a protein kinase C inhibitor (IC50 =25 μM). |
| CSN16839 | (-)-Indolactam V | 90365-57-4 | (-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. |
