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PLK

PLK

货号 产品名 CAS号 信息
CSN16924 SBE13 HCl 1052532-15-6 SBE13 HCl is a potent and selective PLK1 inhibitor with IC50 of 0.2 nM while 875 nM and 66 μM for PLK3 and PLK2. SBE 13 could also induce cell cycle arrest, reduce cell proliferation with EC50 of 5-60 µM, and induce apoptosis in a broad range of human cancer cell lines.
CSN15803 Rigosertib Sodium (Random Configuration) 1225497-78-8 Rigosertib Sodium (Random Configuration) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.
CSN18349 Rigosertib 592542-59-1 Rigosertib is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM and shows 30-fold greater selectivity against PLK2 and no activity to PLK3.
CSN18009 Poloxime 17302-61-3 Poloxime is an analogue of thymoquinone, which bind to the phosphoserine/phosphothreonine recognition site of the polo-box domain of polo-like kinase 1.
CSN18151 LFM-A13 244240-24-2 LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 μM and also inhibits PLK3 with IC50 of 7.2 μM.
CSN16519 HMN-214 173529-46-9 HMN-214 is a potent PLK1 inhibitor an average IC50 of 0.12 μM, and a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.
CSN19103 HMN-176 173529-10-7 HMN-176 is the active derivative of HMN-214 which can alter the cellular spatial orientation of Plk1.
CSN12461 BI-2536 755038-02-9 BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3 and also is a BRD4 inhibitor (IC50= 25 nM).
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