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Potassium Channel

Potassium Channel

货号 产品名 CAS号 信息
CSN20024 XE991 122955-42-4 XE991 is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM).
CSN20025 XE991 2HCl 122955-13-9 XE991 2HCl is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM).
CSN25285 VU0810464 2126040-21-7 VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels.
CSN23185 VU 0463271 1391737-01-1 VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM.
CSN27561 VU0134992 hydrochloride 1052515-91-9 VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV.
CSN25451 Tetraethylammonium chloride 56-34-8 Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.
CSN28441 Tannic Acid 1401-55-4 Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
CSN23781 SKA-31 40172-65-4 SKA 31 is an activator of KCa3.1 and KCa2 channels with EC50 of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.
CSN27571 Ropivacaine mesylate 854056-07-8 Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
CSN27570 Ropivacaine 84057-95-4 Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.
CSN23838 Pinacidil H2O 85371-64-8 Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.
CSN25559 NS 5806 426834-69-7 NS5806, a KV4.3 channel activator, increases peak current amplitude of the potassium channel Kv4.3 with EC50 of 5.3 uM. NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2.
CSN25560 NS19504 327062-46-4 NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM.
CSN21324 Naminidil 220641-11-2 Naminidil is a cyanoguanidine KATP opener.
CSN27562 ML418 1928763-08-9 ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.
CSN18626 ML365 947914-18-3 ML365 is a selective small molecule inhibitor of TASK1 (KCNK3) with IC50 of 4 nM (thallium influx fluorescent assay) and 16 nM (automated electrophysiology assay).
CSN19856 ML 213 489402-47-3 ML213 is an activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels with EC50s of 230 and 510 nM respectively.
CSN25288 ML 297 1443246-62-5 ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM.
CSN18790 Mitiglinide Calcium Hydrate 207844-01-7 Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.
CSN20022 Linopirdine 105431-72-9 Linopirdine is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.
CSN20023 Linopirdine 2HCl 113168-57-3 Linopirdine 2HCl is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.
CSN20179 Isopimaric Acid 5835-26-7 Isopimaric acid, a natural product isolated and purifed from the herbs of Daemonorops draco Blume, potently opens large conductance Ca-activated K+ channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive.
CSN24792 IK1 inhibitor PA-6 500715-03-7 IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
CSN25242 ICA 110381 325457-99-6 ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM.
CSN20444 ICA 069673 582323-16-8 ICA 069673 selectively inhibit KV7.2 (KCNQ2) and KV7.3 (KCNQ3) channel with EC50 of 0.69 μM and has no measurable activity over a panel of cardiac ion channels.
CSN21276 H100 643727-55-3 H100 is a Cl- transport inhibitor, with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger, but no effect against KCl cotransporter, in human erythrocytes.
CSN24161 GSK369796 2HCl 1010411-21-8 GSK369796 is an anti-malaria drug candidate.
CSN18763 Flupirtine Maleate 75507-68-5 Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels. Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors. It exhibits the relaxantion of muscles and neuroprotective.
CSN15660 Daurisoline 70553-76-3 Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN26156 CyPPA 73029-73-9 CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively.
CSN22765 CLP 257 1181081-71-9 CLP 257 is a selective KCC2 K+-Cl- cotransporter activator with EC50 of 616 nM.
CSN23548 Cloperastine HCl 14984-68-0 Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN23809 Cloperastine Fendizoate 85187-37-7 Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN13101 Chlorzoxazone 95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN19508 Amifampridine 54-96-6 Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS.
CSN22235 Almokalant 123955-10-2 Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
CSN21132 Almitrine Mesylate 29608-49-9 Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2+-dependent K+ channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation.
CSN25452 1-EBIO 10045-45-1 Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
CSN25278 A2793 88349-90-0 A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK).
CSN25279 A2764 2HCl   861038-72-4 A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
CSN27560 2,2,2-Trichloroethanol 115-20-8 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
CSN27563 (±)-Naringenin 67604-48-2 (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
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