Potassium Channel | Membrane Transporter/Ion Channel| CSNpharm

Potassium Channel

Potassium Channel
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货号	产品名	CAS号	信息
CSN25285	VU0810464	2126040-21-7	VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels.
CSN29561	VU0071063	333415-38-6	VU0071063 can activate native Kir6.2/SUR1 channels, thereby inhibiting glucose-stimulated calcium entry in isolated mouse pancreatic β cells.
CSN25451	Tetraethylammonium chloride	56-34-8	Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.
CSN68805	Tannins	1401-55-4	Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals.
CSN26259	Talatisamine	20501-56-8	Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is specific K+ channel blocker with hypotensive and antiarrhythmic activities. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons.
CSN27571	Ropivacaine mesylate	854056-07-8	Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
CSN27570	Ropivacaine	84057-95-4	Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.
CSN21820	Quinidine HCl H2O	6151-40-2	Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel.
CSN26266	PD-118057	313674-97-4	PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade. Human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediate repolarization of cardiac action potentials.
CSN19790	Oxypeucedanin	737-52-0	Oxypeucedanin is a natural product with anti-tumor activity, isolated and purified from the root of Angelica dahurica.It is a kind of open-channel blocker of the hKv1.5 channel.
CSN29556	NS 3623	343630-41-1	NS3623 is an activator of both hERG and Kv4.3.
CSN25560	NS19504	327062-46-4	NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM.
CSN29555	NS11021	956014-19-0	NS 11021 is a potent and specific KCa1.1 channels activator.
CSN27562	ML418	1928763-08-9	ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.
CSN25288	ML 297	1443246-62-5	ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM.
CSN21733	Micinicate	39537-99-0	Micinicate, a local anesthetic, can reversibly block transient Na⁺ inward current as well as the steady-state K⁺ outward current.
CSN26468	KCC2 blocker 1	1228439-36-8	KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect[1].
CSN24792	IK1 inhibitor PA-6	500715-03-7	IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
CSN26295	HMR 1556	223749-46-0	HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current.
CSN18763	Flupirtine Maleate	75507-68-5	Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels. Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors. It exhibits the relaxantion of muscles and neuroprotective.
CSN26272	Flindokalner	187523-35-9	Flindokalner, also known BMS-204352, is a neuroprotectant. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors.
CSN10772	Dequalinium Chloride	522-51-0	Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.
CSN15660	Daurisoline	70553-76-3	Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN26156	CyPPA	73029-73-9	CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively.
CSN24262	CLP-290	1181083-81-7	CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257.
CSN23548	Cloperastine HCl	14984-68-0	Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN13101	Chlorzoxazone	95-25-0	Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN26269	BMS-191011	202821-81-6	BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models. It has also shown neuroprotective properties in two distinct animal models of stroke- MCAO in the SHR rat and a normotensive model of focal stroke.
CSN23891	AUT1	1311136-84-1	AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively.
CSN21493	Apamin	24345-16-2	Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca²⁺-activated K+ (SK, KCa2) channels.
CSN26263	Allocryptopine	485-91-6	Allocryptopine, a derivative of tetrahydropalmatine, is an alkaloid that displays antiparasitic, antiarrythmic, antithrombotic and anti-inflammatory activity. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current.
CSN25452	1-EBIO	10045-45-1	Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
CSN25278	A2793	88349-90-0	A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK).
CSN25279	A2764 2HCl	861038-72-4	A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
CSN27560	2,2,2-Trichloroethanol	115-20-8	2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
CSN27563	(±)-Naringenin	67604-48-2	(±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
CSN26454	(+)-KCC2 blocker 1	1228439-71-1	(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].

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