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Potassium Channel
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN25578 | 1,4,10-Trioxa-7,13-diazacyclopentadecane, 7,13-bis[(4-nitrophenyl)methyl]-, dihydrochloride | 1783987-83-6 | VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1. |
| CSN25562 | VU590 | 313505-85-0 | VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1. |
| CSN27561 | VU0134992 hydrochloride | 1052515-91-9 | VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV. |
| CSN29561 | VU0071063 | 333415-38-6 | VU0071063 can activate native Kir6.2/SUR1 channels, thereby inhibiting glucose-stimulated calcium entry in isolated mouse pancreatic β cells. |
| CSN25451 | Tetraethylammonium chloride | 56-34-8 | Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties. |
| CSN68805 | Tannic acid | 1401-55-4 | Tannins (commonly referred to as tannic acid) are water-soluble polyphenols that are present in many plant foods. They have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals. |
| CSN26259 | Talatisamine | 20501-56-8 | Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is specific K+ channel blocker with hypotensive and antiarrhythmic activities. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. |
| CSN26267 | SKA-121 | 1820708-73-3 | SKA-121 is a novel KCa3.1-specific positive gating modulator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively. |
| CSN27571 | Ropivacaine mesylate | 854056-07-8 | Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. |
| CSN27570 | Ropivacaine | 84057-95-4 | Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo. |
| CSN33182 | Rimtuzalcap | 2167246-24-2 | Rimtuzalcap is a modulator of small-conductance calcium-activated potassium channels. |
| CSN21820 | Quinidine hydrochloride monohydrate | 6151-40-2 | Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel. |
| CSN26266 | PD-118057 | 313674-97-4 | PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade. Human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediate repolarization of cardiac action potentials. |
| CSN40150 | Paxilline | 57186-25-1 | Paxilline is a toxic, tremorgenic diterpene indole polycyclic alkaloid molecule produced by Penicillium paxilli. It works as BK channels inhibitor and SERCA inhibitor. |
| CSN19790 | Oxypeucedanin | 737-52-0 | Oxypeucedanin is a natural product with anti-tumor activity, isolated and purified from the root of Angelica dahurica.It is a kind of open-channel blocker of the hKv1.5 channel. |
| CSN25559 | NS5806 | 426834-69-7 | NS5806, a KV4.3 channel activator, increases peak current amplitude of the potassium channel Kv4.3 with EC50 of 5.3 uM. NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. |
| CSN29556 | NS3623 | 343630-41-1 | NS3623 is an activator of both hERG and Kv4.3. |
| CSN25560 | NS19504 | 327062-46-4 | NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM. |
| CSN29555 | NS 11021 | 956014-19-0 | NS 11021 is a potent and specific KCa1.1 channels activator. |
| CSN27562 | ML418 | 1928763-08-9 | ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels. |
| CSN25420 | ML335 | 825658-06-8 | ML335 is a selective activator of both TREK-1 and TREK-2. |
| CSN33141 | MK-7145 | 1255204-84-2 | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). |
| CSN21733 | Nicotinoyl cyclandelate | 39537-99-0 | Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current. |
| CSN21708 | Levcromakalim | 94535-50-9 | Levcromakalim is an activator of ATP-sensitive K+ channel (KATP). |
| CSN26468 | KCC2 blocker 1 | 1228439-36-8 | KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect[1]. |
| CSN25450 | JNJ 303 | 878489-28-2 | JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP). |
| CSN37908 | Iberiotoxin | 129203-60-7 | Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca2+-activated K+ channel inhibitor with a Kd of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels. |
| CSN26295 | HMR 1556 | 223749-46-0 | HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current. |
| CSN22064 | GAL-021 | 1380341-99-0 | GAL-021 a new intravenous Potassium Channel KCa1.1 blocker. |
| CSN18763 | Flupirtine Maleate | 75507-68-5 | Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels. Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors. It exhibits the relaxantion of muscles and neuroprotective. |
| CSN26272 | Flindokalner | 187523-35-9 | Flindokalner, also known BMS-204352, is a neuroprotectant. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. |
| CSN10772 | Dequalinium Chloride | 522-51-0 | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. |
| CSN26156 | CyPPA | 73029-73-9 | CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively. |
| CSN24262 | CLP290 | 1181083-81-7 | CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257. |
| CSN23548 | Cloperastine hydrochloride | 14984-68-0 | Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
| CSN13101 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM. |
| CSN26269 | BMS-191011 | 202821-81-6 | BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models. It has also shown neuroprotective properties in two distinct animal models of stroke- MCAO in the SHR rat and a normotensive model of focal stroke. |
| CSN23891 | AUT1 | 1311136-84-1 | AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively. |
| CSN21493 | Apamin | 24345-16-2 | Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels. |
| CSN24263 | AM-92016 hydrochloride | 133229-11-5 | AM 92016 is a KV channel blocker. |
| CSN26263 | Allocryptopine | 485-91-6 | Allocryptopine, a derivative of tetrahydropalmatine, is an alkaloid that displays antiparasitic, antiarrythmic, antithrombotic and anti-inflammatory activity. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current. |
| CSN25452 | 1-EBIO | 10045-45-1 | Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes. |
| CSN27560 | 2,2,2-Trichloroethanol | 115-20-8 | 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). |
| CSN27563 | (±)-Naringenin | 67604-48-2 | (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes. |
| CSN26454 | (+)-KCC2 blocker 1 | 1228439-71-1 | (+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1]. |
| CSN41154 | 5-Hydroxydecanoate sodium | 71186-53-3 | |
| CSN38596 | ASP2905 | 792184-90-8 | |
| CSN63426 | Iptakalim hydrochloride | 642407-63-4 | |
| CSN79315 | OSK-1 | 183815-75-0 | |
| CSN84015 | Mosapride citrate dihydrate | 636582-62-2 |
