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Potassium Channel
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN25285 | VU0810464 | 2126040-21-7 | VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels. |
CSN23185 | VU 0463271 | 1391737-01-1 | VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM. |
CSN29561 | VU0071063 | 333415-38-6 | VU0071063 can activate native Kir6.2/SUR1 channels, thereby inhibiting glucose-stimulated calcium entry in isolated mouse pancreatic β cells. |
CSN25451 | Tetraethylammonium chloride | 56-34-8 | Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties. |
CSN28441 | Tannic Acid | 1401-55-4 | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
CSN26259 | Talatisamine | 20501-56-8 | Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is specific K+ channel blocker with hypotensive and antiarrhythmic activities. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. |
CSN27571 | Ropivacaine mesylate | 854056-07-8 | Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. |
CSN27570 | Ropivacaine | 84057-95-4 | Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo. |
CSN21820 | Quinidine HCl H2O | 6151-40-2 | Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel. |
CSN26266 | PD-118057 | 313674-97-4 | PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade. Human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediate repolarization of cardiac action potentials. |
CSN29556 | NS 3623 | 343630-41-1 | NS3623 is an activator of both hERG and Kv4.3. |
CSN25560 | NS19504 | 327062-46-4 | NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM. |
CSN29555 | NS11021 | 956014-19-0 | NS 11021 is a potent and specific KCa1.1 channels activator. |
CSN27562 | ML418 | 1928763-08-9 | ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels. |
CSN25288 | ML 297 | 1443246-62-5 | ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. |
CSN21733 | Micinicate | 39537-99-0 | Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current. |
CSN21708 | Levcromakalim | 94535-50-9 | Levcromakalim is an activator of ATP-sensitive K+ channel (KATP). |
CSN26468 | KCC2 blocker 1 | 1228439-36-8 | KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect[1]. |
CSN24792 | IK1 inhibitor PA-6 | 500715-03-7 | IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3]. |
CSN26295 | HMR 1556 | 223749-46-0 | HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current. |
CSN24161 | GSK369796 2HCl | 1010411-21-8 | GSK369796 is an anti-malaria drug candidate. |
CSN22064 | GAL-021 | 1380341-99-0 | GAL-021 a new intravenous Potassium Channel KCa1.1 blocker. |
CSN26272 | Flindokalner | 187523-35-9 | Flindokalner, also known BMS-204352, is a neuroprotectant. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. |
CSN15660 | Daurisoline | 70553-76-3 | Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel. |
CSN26156 | CyPPA | 73029-73-9 | CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively. |
CSN24262 | CLP-290 | 1181083-81-7 | CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257. |
CSN23548 | Cloperastine HCl | 14984-68-0 | Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
CSN23809 | Cloperastine Fendizoate | 85187-37-7 | Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
CSN13101 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM. |
CSN26269 | BMS-191011 | 202821-81-6 | BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models. It has also shown neuroprotective properties in two distinct animal models of stroke- MCAO in the SHR rat and a normotensive model of focal stroke. |
CSN23891 | AUT1 | 1311136-84-1 | AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively. |
CSN21493 | Apamin | 24345-16-2 | Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels. |
CSN26263 | Allocryptopine | 485-91-6 | Allocryptopine, a derivative of tetrahydropalmatine, is an alkaloid that displays antiparasitic, antiarrythmic, antithrombotic and anti-inflammatory activity. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current. |
CSN25452 | 1-EBIO | 10045-45-1 | Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes. |
CSN25278 | A2793 | 88349-90-0 | A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). |
CSN25279 | A2764 2HCl | 861038-72-4 | A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability. |
CSN27560 | 2,2,2-Trichloroethanol | 115-20-8 | 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). |
CSN27563 | (±)-Naringenin | 67604-48-2 | (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes. |
CSN26454 | (+)-KCC2 blocker 1 | 1228439-71-1 | (+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1]. |