Potassium Channel | Membrane Transporter/Ion Channel| CSNpharm

Potassium Channel

Potassium Channel
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货号	产品名	CAS号	信息
CSN25285	VU0810464	2126040-21-7	VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels.
CSN23185	VU 0463271	1391737-01-1	VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM.
CSN29561	VU0071063	333415-38-6	VU0071063 can activate native Kir6.2/SUR1 channels, thereby inhibiting glucose-stimulated calcium entry in isolated mouse pancreatic β cells.
CSN25451	Tetraethylammonium chloride	56-34-8	Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.
CSN28441	Tannic Acid	1401-55-4	Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
CSN26259	Talatisamine	20501-56-8	Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is specific K+ channel blocker with hypotensive and antiarrhythmic activities. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons.
CSN27571	Ropivacaine mesylate	854056-07-8	Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
CSN27570	Ropivacaine	84057-95-4	Ropivacaine is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.
CSN21820	Quinidine HCl H2O	6151-40-2	Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel.
CSN26266	PD-118057	313674-97-4	PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade. Human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediate repolarization of cardiac action potentials.
CSN29556	NS 3623	343630-41-1	NS3623 is an activator of both hERG and Kv4.3.
CSN25560	NS19504	327062-46-4	NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM.
CSN29555	NS11021	956014-19-0	NS 11021 is a potent and specific KCa1.1 channels activator.
CSN27562	ML418	1928763-08-9	ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.
CSN25288	ML 297	1443246-62-5	ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM.
CSN21733	Micinicate	39537-99-0	Micinicate, a local anesthetic, can reversibly block transient Na⁺ inward current as well as the steady-state K⁺ outward current.
CSN21708	Levcromakalim	94535-50-9	Levcromakalim is an activator of ATP-sensitive K⁺ channel (KATP).
CSN26468	KCC2 blocker 1	1228439-36-8	KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect[1].
CSN24792	IK1 inhibitor PA-6	500715-03-7	IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
CSN26295	HMR 1556	223749-46-0	HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current.
CSN24161	GSK369796 2HCl	1010411-21-8	GSK369796 is an anti-malaria drug candidate.
CSN22064	GAL-021	1380341-99-0	GAL-021 a new intravenous Potassium Channel KCa1.1 blocker.
CSN26272	Flindokalner	187523-35-9	Flindokalner, also known BMS-204352, is a neuroprotectant. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors.
CSN15660	Daurisoline	70553-76-3	Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN26156	CyPPA	73029-73-9	CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively.
CSN24262	CLP-290	1181083-81-7	CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257.
CSN23548	Cloperastine HCl	14984-68-0	Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN23809	Cloperastine Fendizoate	85187-37-7	Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN13101	Chlorzoxazone	95-25-0	Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM.
CSN26269	BMS-191011	202821-81-6	BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models. It has also shown neuroprotective properties in two distinct animal models of stroke- MCAO in the SHR rat and a normotensive model of focal stroke.
CSN23891	AUT1	1311136-84-1	AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively.
CSN21493	Apamin	24345-16-2	Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca²⁺-activated K+ (SK, KCa2) channels.
CSN26263	Allocryptopine	485-91-6	Allocryptopine, a derivative of tetrahydropalmatine, is an alkaloid that displays antiparasitic, antiarrythmic, antithrombotic and anti-inflammatory activity. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current.
CSN25452	1-EBIO	10045-45-1	Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
CSN25278	A2793	88349-90-0	A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK).
CSN25279	A2764 2HCl	861038-72-4	A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
CSN27560	2,2,2-Trichloroethanol	115-20-8	2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
CSN27563	(±)-Naringenin	67604-48-2	(±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
CSN26454	(+)-KCC2 blocker 1	1228439-71-1	(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1].

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