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Potassium Channel
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN20024 | XE991 | 122955-42-4 | XE991 is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). |
CSN20025 | XE 991 2HCl | 122955-13-9 | XE991 2HCl is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). |
CSN25285 | VU0810464 | 2126040-21-7 | VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels. |
CSN23185 | VU0463271 | 1391737-01-1 | VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM. |
CSN16050 | VU 0240551 | 893990-34-6 | VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). |
CSN12970 | Vernakalant HCl | 748810-28-8 | Vernakalant HCl prolongs repolarization by blocking atrial potassium channels, it's a class III antiarrhythmics. |
CSN16112 | Vonoprazan Fumarate | 881681-01-2 | TAK-438, a potassium proton pump inhibitor, can reversibly inhibit H+/K+ ATPase with IC50 of 17 nM and does not affect Na+/K+ ATPase. It also controls gastric acid secretion. |
CSN18522 | 1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine | 881681-00-1 | TAK-438 Free Base is a blocker of potassium-competitive proton pump that reversibly inhibits H+/K+ ATPase with IC50 of 17 nM at pH 6.5 while do not affect on Na+/K+ ATPase activity. It has been used to treatment of erosive esophagitis and gastroduodenal ulcer. |
CSN16469 | Sophocarpine | 6483-15-4 | Sophocarpine is a naturally-occuring HERG K+ channel blocker with IC50 ranging in 100-300 μM found from plant Sophora flavescens. |
CSN23781 | SKA-31 | 40172-65-4 | SKA 31 is an activator of KCa3.1 and KCa2 channels with EC50 of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively. |
CSN15798 | RPR-260243 | 668463-35-2 | RPR-260243 is an activator of HERG which modifies HERG currents inhibited by dofetilide (IC50 = 58 nM) and shows little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. |
CSN23838 | Pinacidil monohydrate | 85371-64-8 | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. |
CSN18234 | NS6180 | 353262-04-1 | NS-6180 is a channel blocker of KCa3.1 (IC50= 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation. |
CSN13720 | NS309 | 18711-16-5 | NS-309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels). It increases Ca2+ sensitivity and displays no activity at BK channels. |
CSN17090 | Nifekalant HCl | 130656-51-8 | Nifekalant HCl is an antiarrhythmic shown to be effective against ventricular tachyarrhythmias by inhibiting HERG channels in a voltage- and frequency-dependent manner. |
CSN12869 | Nicorandil | 65141-46-0 | Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). |
CSN21324 | Naminidil | 220641-11-2 | Naminidil is a cyanoguanidine KATP opener. |
CSN20652 | ML402 | 298684-44-3 | ML402 is a selective TREK-1 activator. |
CSN18626 | ML365 | 947914-18-3 | ML365 is a selective small molecule inhibitor of TASK1 (KCNK3) with IC50 of 4 nM (thallium influx fluorescent assay) and 16 nM (automated electrophysiology assay). |
CSN17790 | ML277 | 1401242-74-7 | ML277 is a potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. |
CSN19856 | ML213 | 489402-47-3 | ML213 is an activator of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels with EC50s of 230 and 510 nM respectively. |
CSN13712 | ML133 HCl | 1222781-70-5 | ML133 HCl selectively inhibit Kir2.1 with IC50 of 1.8 μM at pH7.4 and 290 nM at pH8.5 and has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. |
CSN25288 | ML 297 | 1443246-62-5 | ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. |
CSN18790 | Calcium (S)-2-benzyl-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)-4-oxobutanoate dihydrate | 207844-01-7 | Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist. |
CSN20022 | Linopirdine | 105431-72-9 | Linopirdine is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug. |
CSN20023 | 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride | 113168-57-3 | Linopirdine 2HCl is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug. |
CSN20179 | Isopimaric acid | 5835-26-7 | Isopimaric acid, a natural product isolated and purifed from the herbs of Daemonorops draco Blume, potently opens large conductance Ca-activated K+ channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive. |
CSN19691 | BMS-919373 | 1272353-82-8 | IKur inhibitor C25 is a selective IKur inhibitor for the potential treatment of atrial fibrillation. |
CSN24792 | IK1 inhibitor PA-6 | 500715-03-7 | IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3]. |
CSN25242 | ICA 110381 | 325457-99-6 | ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM. |
CSN20444 | ICA-069673 | 582323-16-8 | ICA 069673 selectively inhibit KV7.2 (KCNQ2) and KV7.3 (KCNQ3) channel with EC50 of 0.69 μM and has no measurable activity over a panel of cardiac ion channels. |
CSN21276 | H100 | 643727-55-3 | H100 is a Cl- transport inhibitor, with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger, but no effect against KCl cotransporter, in human erythrocytes. |
CSN24161 | GSK369796 2HCl | 1010411-21-8 | GSK369796 is an anti-malaria drug candidate. |
CSN16794 | Glimepiride | 93479-97-1 | Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 3.0 nM in pancreatic β-cells with fewer cardiac actions. It is used in the treatment of type 2 diabetes mellitus. |
CSN16729 | Gliclazide | 21187-98-4 | Gliclazide is a blocker of pancreatic β-cell ATP-sensitive potassium channels with IC50 of 184 nM in murine. It belongs to the sulfonylurea class of insulin secretagoguesIt. Gliclazide is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
CSN13087 | E-4031 | 113559-13-0 | E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel. |
CSN16013 | Doxapram HCl | 7081-53-0 | Doxapram HCl, a respiratory stimulant, exhibits inhibition of TASK-1 (EC50 = 410 nM), TASK-3 (EC50 = 37 nM) and TASK-1/TASK-3 heterodimeric (EC50 = 9 nM) channel function. It is widely used in central nervous system excitability and directly stimulate the medullary respiratory or vascular movement center. |
CSN15735 | N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide | 115256-11-6 | Dofetilide is a potassium channel blocker that acts as a class III antiarrhythmic drug. It is used for the treatment of atrial fibrillation and flutter. |
CSN15660 | Daurisoline | 70553-76-3 | Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel. |
CSN22765 | CLP257 | 1181081-71-9 | CLP 257 is a selective KCC2 K+-Cl- cotransporter activator with EC50 of 616 nM. |
CSN23809 | Cloperastine fendizoate | 85187-37-7 | Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
CSN17990 | BMS-191095 | 166095-21-2 | BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. |
CSN17898 | Azimilide 2HCl | 149888-94-8 | Azimilide 2HCl, a class III antiarrhythmic compound, blocks the Kv7.1 and Kv11.1 patassium channels. It also inhibits Na+/Ca2+ exchanger in vitro. |
CSN19508 | Amifampridine | 54-96-6 | Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS. |
CSN21132 | Almitrine Bismesylate | 29608-49-9 | Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2+-dependent K+ channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation. |
CSN25278 | A2793 | 88349-90-0 | A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). |
CSN25279 | A2764 2HCl | 861038-72-4 | A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability. |