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Potassium Channel
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12821 | UK-78282 hydrochloride | 136647-02-4 | UK-78282 is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively) which suppresses T lymphocyte mitogenesis and leads to membrane depolarization and also blocks KV1.4 expressed in heart and brain. |
| CSN12701 | TRAM-34 | 289905-88-0 | TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). |
| CSN12105 | N-(Butylcarbamoyl)-4-methylbenzenesulfonamide | 64-77-7 | Tolbutamide is a potassium channel blocker, sulfonylurea oral hypoglycemic drug. |
| CSN12056 | 1-(4-(tert-Butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol | 50679-08-8 | Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM. |
| CSN12384 | 2,2-Bis(4-fluorophenyl)-2-phenylacetamide | 289656-45-7 | Senicapoc is a potent and selective Gardos channel blocker and blocks Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively. |
| CSN11584 | Repaglinide | 135062-02-1 | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| CSN10033 | PAP-1 | 870653-45-5 | PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity. |
| CSN12824 | NS1643 | 448895-37-2 | NS-1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM. |
| CSN12339 | NS-1619 | 153587-01-0 | NS-1619 is a selective large conductance Ca2+-activated K+-channel activator. |
| CSN11558 | Nigericin sodium salt | 28643-80-3 | Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore. |
| CSN12478 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| CSN12556 | Mitiglinide calcium | 145525-41-3 | Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
| CSN10129 | 2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide sulfate | 210357-39-4 | Minoxidil sulfate is a K+ channel agonist and a strong vascular smooth muscle relaxant. It has been shown to relax norepinephrine contraction, and is reported to be a vasodilator. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability. |
| CSN11450 | 2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide | 38304-91-5 | Minoxidil is an antihypertensive vasodilator medication. |
| CSN11163 | Hydralazine HCl | 304-20-1 | Hydralazine HCl is a direct-acting vasodilator that is used as an antihypertensive agent. |
| CSN11103 | Glisoxepide | 25046-79-1 | Glisoxepide is an orally available anti-diabetic drug from the group of sulfonylureas. |
| CSN11102 | Gliquidone | 33342-05-1 | Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| CSN11101 | Glipizide | 29094-61-9 | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| CSN10055 | Glibenclamide | 10238-21-8 | Glibenclamide is a sulfonylurea compound that modulates insulin production. |
| CSN10543 | Flupirtine | 56995-20-1 | Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. |
| CSN10860 | Doxapram | 309-29-5 | Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| CSN12647 | 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| CSN10370 | Azimilide | 149908-53-2 | Azimilide is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. |
| CSN10287 | Amiodarone | 1951-25-3 | Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
| CSN12596 | Amiodarone HCl | 19774-82-4 | Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
| CSN10068 | Ajmaline | 4360-12-7 | Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent. |
| CSN18752 | 20-HETE | 79551-86-3 | 20-HETE is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. |
