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PPAR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN26416 | Tesaglitazar | 251565-85-2 | Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1]. |
| CSN18774 | T0070907 | 313516-66-4 | T0070907 is an antagonist of PPARγ with IC50 of 1 nM. |
| CSN20285 | Suksdorfin | 53023-17-9 | Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPARγ activation. |
| CSN23126 | SR1664 | 1338259-05-4 | SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity. |
| CSN23127 | Mifobate | 76541-72-5 | SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. |
| CSN32930 | Seladelpar lysine | 928821-40-3 | Seladelpar lysine is a selective PPAR-δ agonist. |
| CSN20554 | Seladelpar | 851528-79-5 | Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor δ (PPARδ) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis. |
| CSN22093 | Saroglitazar magnesium | 1639792-20-3 | Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ in HepG2 cells, respectively. |
| CSN16902 | Saroglitazar | 495399-09-2 | Saroglitazar is a peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3 nM in HepG2 cells, respectively. |
| CSN33127 | Sodium (E)-2-(4-((3-(4-fluorophenyl)-3-(4-(3-morpholinoprop-1-yn-1-yl)phenyl)allyl)oxy)-2-methylphenoxy)acetate | 1604815-32-8 | REN-001 is a PPARdelta agonist. |
| CSN22489 | Pparδ agonist | 942594-93-6 | PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10. |
| CSN22490 | Pparδ agonist 1 | 1902161-12-9 | Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases. |
| CSN18945 | (R)-2-(3-((Benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid | 848259-27-8 | Pemafibrateis a selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity. |
| CSN18946 | Pemafibrate Racemate | 848258-31-1 | Pemafibrate racemate is a selective PPARα modulator (SPPARMα). |
| CSN25412 | Oroxin A | 57396-78-8 | Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence. |
| CSN20649 | Oleoylethanolamide | 111-58-0 | Oleoylethanolamide is a lipid mediator and analog of anandamide that is involved in peripheral regulation of feeding. It is also a selective GPR55 agonist (EC50 values are 0.44, > 30 and > 30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM). |
| CSN13703 | MK-886 | 118414-82-7 | MK886 is an inhibitor of 5-lipoxygenase activating protein (FLAP), PPARα, and the biosynthesis of leukotriene (LT). |
| CSN20225 | MHY553 | 6265-56-1 | MHY553, a PPARα agonist, alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. |
| CSN25571 | MA-0204 | 2095128-17-7 | MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. It is potential for Duchene Muscular Dystrophy treatment. |
| CSN23900 | LJ570 | 2252488-69-8 | LJ570 is the first PPARα/γ dual agonist with EC50 values of 1.05 and 0.12 μM, respectively. |
| CSN33142 | Leriglitazone | 146062-44-4 | Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist. |
| CSN20539 | Lanifibranor | 927961-18-0 | IVA-337 is a agonist of peroxisome proliferator-activated receptors (PPAR) which is widely used in the study of lung fibrosis and pulmonary hypertension. |
| CSN21901 | Imiglitazar | 250601-04-8 | Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM, respectively. |
| CSN27564 | Gypenoside XLIX | 94987-08-3 | Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells. |
| CSN26116 | GW7647 | 265129-71-3 | GW7647 is a potent human PPARα agonist with EC50 value of 6nM. |
| CSN22426 | GW6471 | 880635-03-0 | GW 6471 is a potent PPARα antagonist. |
| CSN22845 | GW1929 hydrochloride | 1217466-21-1 | GW 1929 HCl is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist with pEC50 of 8.05 for human PPARγ. |
| CSN22403 | Fonadelpar | 515138-06-4 | Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy. |
| CSN15096 | Ficusin A | 173429-83-9 | Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn. |
| CSN17195 | FH535 | 108409-83-2 | FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. |
| CSN18750 | Fenofibric acid | 42017-89-0 | Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2. |
| CSN22800 | Edaglitazone | 213411-83-7 | Edaglitazone is a potent and selective PPARγ agonist with EC50 of 35.61 nM. |
| CSN27742 | Diflapolin | 724453-98-9 | Diflapolin is a dual inhibitor of both FLAP and sEH. It inhibited 5-LOX product formation in intact human monocytes and neutrophils with IC50 = 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50 = 20 nM). |
| CSN17750 | DG172 dihydrochloride | 1361504-77-9 | DG172 2HCl is a PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties. |
| CSN26559 | CUDA | 479413-68-8 | CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2]. |
| CSN22773 | CP-775146 | 702680-17-9 | CP 775146 is a selective, high affinity PPARα agonist with Ki of 24.5 nM. |
| CSN25193 | Cinnamyl Alcohol | 104-54-1 | Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. |
| CSN22759 | Ciglitazone | 74772-77-3 | Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro. |
| CSN18278 | CDDO-Im | 443104-02-7 | CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPARγ agonist. |
| CSN17378 | BMS-687453 | 1000998-59-3 | BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. |
| CSN18081 | Balaglitazone | 199113-98-9 | Balaglitazone is a partial agonist of PPAR-γ. |
| CSN22706 | BADGE | 1675-54-3 | BADGE is a PPARγ antagonist. |
| CSN21934 | AVE-8134 | 304025-09-0 | AVE-8134 is a potent PPARα agonist with EC50 of 100 and 3000 nM for human and rodent PPARα receptor, respectively. |
| CSN22075 | Arhalofenate | 24136-23-0 | Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes. |
| CSN20181 | AMG131 | 315224-26-1 | AMG-131 is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs. |
| CSN51362 | SR 16832 | 2088135-12-8 | |
| CSN62538 | (S)-Coriolic acid | 29623-28-7 | |
| CSN51560 | (9Z,11E)-13-Oxooctadeca-9,11-dienoic acid | 54739-30-9 |
