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PPAR

PPAR

货号 产品名 CAS号 信息
CSN26416 Tesaglitazar 251565-85-2 Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].
CSN18774 T0070907 313516-66-4 T0070907 is an antagonist of PPARγ with IC50 of 1 nM.
CSN20285 Suksdorfin 53023-17-9 Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPARγ activation.
CSN23127 SR 202 76541-72-5 SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
CSN33127 REN-001 1604815-32-8 REN-001 is a PPARdelta agonist.
CSN22489 Pparδ Agonist 942594-93-6 PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10.
CSN22490 Pparδ Agonist 1 1902161-12-9 Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
CSN25412 Oroxin A 57396-78-8 Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
CSN20649 Oleoylethanolamide 111-58-0 Oleoylethanolamide is a lipid mediator and analog of anandamide that is involved in peripheral regulation of feeding. It is also a selective GPR55 agonist (EC50 values are 0.44, > 30 and > 30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM).
CSN13703 MK-886 118414-82-7 MK886 is an inhibitor of 5-lipoxygenase activating protein (FLAP), PPARα, and the biosynthesis of leukotriene (LT).
CSN20225 MHY553 6265-56-1 MHY553, a PPARα agonist, alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging.
CSN23900 LJ570 2252488-69-8 LJ570 is the first PPARα/γ dual agonist with EC50 values of 1.05 and 0.12 μM, respectively.
CSN33142 Leriglitazone 146062-44-4 Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist.
CSN27564 Gypenoside XLIX 94987-08-3 Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells.
CSN26116 GW7647 265129-71-3 GW7647 is a potent human PPARα agonist with EC50 value of 6nM.
CSN22426 GW 6471 880635-03-0 GW 6471 is a potent PPARα antagonist.
CSN16260 Gemfibrozil 25812-30-0 Gemfibrozil is an agonist of PPARα. It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides.
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy.
CSN18750 Fenofibric Acid 42017-89-0 Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2.
CSN26559 CUDA 479413-68-8 CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].
CSN25193 Cinnamyl alcohol 104-54-1 Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon.
CSN22759 Ciglitazone 74772-77-3 Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-γ.
CSN22706 BADGE 1675-54-3 BADGE is a PPARγ antagonist.
CSN21934 AVE-8134 304025-09-0 AVE-8134 is a potent PPARα agonist with EC50 of 100 and 3000 nM for human and rodent PPARα receptor, respectively.
CSN22075 MBX 102 24136-23-0 Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes.
CSN20181 AMG-131 315224-26-1 AMG-131 is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs.
CSN51362 SR 16832 2088135-12-8
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