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PPAR

PPAR

货号 产品名 CAS号 信息
CSN12217 Wy-14643 50892-23-4 Wy-14643 is an agonist of PPARα with EC50 of 0.63 μM that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc..
CSN12155 Troglitazone 97322-87-7 Troglitazone is a PPARγ agonist with EC50 of 780 nM in murine and 555 nM in human. It has no activity at PPARα or PPARδ and can act as an anti-diabetic agent.
CSN18774 T0070907 313516-66-4 T0070907 is an antagonist of PPARγ with IC50 of 1 nM.
CSN20285 Suksdorfin 53023-17-9 Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPARγ activation.
CSN23127 SR 202 76541-72-5 SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
CSN12570 Rosiglitazone Maleate   155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPARγ) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN12512 Rosiglitazone   122320-73-4 Rosiglitazone is a selective agonist of PPARγ with EC50 of 60 nM, and has no effect on PPARα and PPARβ. It is an insulin sensitizing and potent antihyperglycemic agent.
CSN12489 Pioglitazone HCl   112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN11647 Palmitoylethanolamide 544-31-0 Palmitoylethanolamide, endogenous fatty acid amide, is an agonist of PPAR-α in vitro with an EC50 value of 3.1 ± 0.4 μM. It can be used for preventing the infection of virus.
CSN25412 Oroxin A 57396-78-8 Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
CSN20649 Oleoylethanolamide 111-58-0 Oleoylethanolamide is a lipid mediator and analog of anandamide that is involved in peripheral regulation of feeding. It is also a selective GPR55 agonist (EC50 values are 0.44, > 30 and > 30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM).
CSN13703 MK-886 118414-82-7 MK886 is an inhibitor of 5-lipoxygenase activating protein (FLAP), PPARα, and the biosynthesis of leukotriene (LT).
CSN20225 MHY553 6265-56-1 MHY553, a PPARα agonist, alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging.
CSN27564 Gypenoside XLIX 94987-08-3 Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells.
CSN13142 GW0742 317318-84-6 GW0742 is an agonist of PPARδ with EC50 of 1.1 nM. It can protect right heart from hypertrophy and enhance lipid metabolism in heart. It also works as an antagonist of vitamin D receptor.
CSN22426 GW 6471 880635-03-0 GW 6471 is a potent PPARα antagonist.
CSN15822 GSK3787 188591-46-0 GSK3787 selectively and irreversibly antagonizes PPARδ with pIC50 of 6.6 with no significant effect on hPPARα or hPPARγ.
CSN15777 GSK0660 1014691-61-2 GSK0660 is a selective antagonist of PPARβ/δ and exhibits inverse agonist effects when used alone.
CSN16260 Gemfibrozil 25812-30-0 Gemfibrozil is an agonist of PPARα. It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides.
CSN18750 Fenofibric Acid 42017-89-0 Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2.
CSN12680 Fenofibrate 49562-28-9 Fenofibrate is an agonist of PPARα (EC50 = 30 μM) and an inhibitor of CYP2C19 (IC50 = 0.2 μM) and CYP2B6 (IC50 = 0.7 μM). Fenofibrate is a fibric acid derivative and used to treat hypercholesterolemia and hypertriglyceridemia.
CSN13948 Eupatilin 22368-21-4 Eupatilin is an activiator of PPARα. It is a lipohilic flavonoid extracted from artemisia species with antioxidant, anti-tumor, and anti-inflammatory activities.
CSN13070 Clofibric Acid 882-09-7 Clofibric acid is an agonist of PPARα and can act as a hypolipidemic agent.
CSN22759 Ciglitazone 74772-77-3 Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro.
CSN18278 CDDO-Im 443104-02-7 CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPARγ agonist.
CSN17378 BMS-687453 1000998-59-3 BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-γ.
CSN22706 BADGE 1675-54-3 BADGE is a PPARγ antagonist.
CSN12767 4-(4-Hydroxyphenyl)-2-Butanone 5471-51-2 4-(4-Hydroxyphenyl)-2-butanone is the primary aroma compound of red raspberries and shows PPAR-α agonistic activity.
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