CAS No.: 1026016-83-0
(+)-Tetrabenazine/(+)-丁苯那嗪 Catalog No. CSN15704
Synonyms: (+)-TBZ;(3R,11bR)-TBZ;(3R,11bR)-Tetrabenazine
Tetrabenazine (+)- is a potent, selective and reversible VMAT-2 (vesicular monoamine transporter-2) inhibitor with Ki value of 100 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03567291 Tourette Syndrome Phase 3 Recruiting May 22, 2021 United States, Alabama ... more >> Teva Investigational Site 046-0104 Recruiting Dothan, Alabama, United States, 36303 United States, California Teva Investigational Site 046-0101 Recruiting Sacramento, California, United States, 95815 United States, Georgia Teva Investigational Site 046-0116 Recruiting Atlanta, Georgia, United States, 30331 United States, New York Teva Investigational Site 046-0102 Recruiting Rochester, New York, United States, 14618 United States, Texas Teva Investigational Site 060-0163 Recruiting Fort Worth, Texas, United States, 76104 United States, Washington Teva Investigational Site 060-0162 Recruiting Everett, Washington, United States, 98201-4077 Canada Teva Investigational Site 046-0201 Recruiting Ajax, Canada, L1Z0M1 Teva Investigational Site 046-0202 Recruiting Ottawa, Canada, K2G 1W2 Collapse << NCT01688037 - - Completed - - NCT01688037 Tardive Dyskinesia Phase 2 Completed - - - 更多
- 参考文献
- [1] Podurgiel SJ, Yohn SE, et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298(Pt B):188-91.
- [2] Peter D, Vu T, et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271(6):2979-86.
- [3] Peter D, Vu T, Edwards RH. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996;271(6):2979-2986.
- [4] Podurgiel SJ, Yohn SE, Dortche K, Correa M, Salamone JD. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016;298(Pt B):188-191.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1026016-83-0 | 储存条件 |
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| 分子式 | C19H27NO3 | 运输 | 蓝冰 | |||
| 分子量 | 317.42 | 别名 | (+)-TBZ;(3R,11bR)-TBZ;(3R,11bR)-Tetrabenazine;Tetrabenazine ((+)-);(+)-丁苯那嗪 | |||
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动物实验配方 |
