生物活性

• 描述(-)-Gallocatechin, a natural product isolated and purified from the wood of Acacia catechu (L.F.) Willd., has moderate affinity to the human cannabinoid receptor. E. brasiliensis has an important anti-inflammatory activity, and that this effect by the presence of the compounds catechin and gallocatechin^[3]. GC (gallocatechin) -AgNPs (silver nanoparticles)-CGP dressing on diabetic wound rats modulated oxidative stress and inflammation with elevated growth factors; increased collagen synthesis thereby significantly improved the wound healing and could be beneficial for the management of diabetic wounds^[4]. BC (baicalin) and GC (gallocatechin) produced concentration-dependent anti-aggregation effects with GC producing a more pronounced effect than BC^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01360320	Colorectal Serrated Adenomas ... more >> Colorectal Tubular Adenomas Colorectal Villous Adenomas Colorectal Tubulovillous Adenomas Collapse <<	Phase 2	Unknown	March 2018	Germany ... more >> Ostalb-Klinikum Aalen, Medizinische Klinik 1, Sekretariat Prof. Kleber Recruiting Aalen, Germany, 73430 Contact: Caroline Walny       caroline.walny@ostalb-klinikum.de    Principal Investigator: Gerhard Kleber, MD          Klinikum Altenburger Land, Gastroenterologie Not yet recruiting Altenburg, Germany, 04600 Contact: Michael Repp, MD       michael.repp@klinikum-altenburgerland.de    Principal Investigator: Michael Repp, MD          Klinikum Augsburg, III. Med. Klinik Recruiting Augsburg, Germany, 86156 Contact: Tanja Hilmer       Tanja.Hilmer@klinikum-augsburg.de    Krankenhaus Bietigheim-Bissingen, Klinik für Innere Medizin, Gastroenterologie, Hämato-Onkologie Recruiting Bietigheim-Bissingen, Germany, 74321 Contact: Ulla Hegmann       hegmul01@kliniken-lb.de    Principal Investigator: Siegfried Walker, MD          Krankenhaus Buchholz, Abteilung Innere Medizin Recruiting Buchholz, Germany, 21244 Contact: Dirk Fahrenholz, MD       Dirk.Fahrenholz@krankenhaus-buchholz.de    Principal Investigator: Dirk Fahrenholz, MD          Kliniken der Stadt Köln gGmbH, Krankenhaus Holweide -Medizinische Klinik- Recruiting Cologne, Germany Contact: Claudia Kaiser-Stolz       Kaiser-Stolz@kliniken-koeln.de    Principal Investigator: Ulrich Huegle, MD          Klinikum Esslingen, Klinik für Innere Medizin, Onkologie, Gastroenterologie Recruiting Esslingen, Germany, 73730 Contact: Stephanie Klink       s.klink@kliniken-es.de    Principal Investigator: Michael Geissler, MD          Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Klinik und Poliklinik für Innere Medizin A Recruiting Greifswald, Germany, 17475 Contact: Eckhard Weber       eckhard.weber@uni-greifswald.de    Principal Investigator: Julia Mayerle, MD          Dr. Zeisler, Praxis für Innere Medizin und Gastroenterologie Recruiting Halle, Germany, 06108 Contact: Brigitte Schneider       gastrozeisler@yahoo.de    Principal Investigator: Thomas Zeisler, MD          Dres. Fechner/Behrens/Steudel - Gastroenterologisch-Onkologische Praxisklinik Recruiting Halle, Germany, 06108 Contact: Anja Schlenk       bsf@gastro-halle.de    Principal Investigator: Ruediger Behrens, MD          Dr. Frank-Gleich Praxis für Innere Medizin und Gastroenterologie Recruiting Halle, Germany, 06110 Contact: Ute Kabisch       u.kabisch@onkomedic.de    Principal Investigator: Stefanie Frank-Gleich, MD          Universitätsklinikum Halle, Klinik für Innere Medizin I Recruiting Halle, Germany, 06120 Contact: Teuber Evelin       evelin.teuber@medizin.uni-halle.de    Principal Investigator: Thomas Seufferlein, MD          Sub-Investigator: Thomas J. Ettrich, MD          Klinikum Ludwigsburg, Medizinische Klinik I Recruiting Ludwigsburg, Germany, 71640 Contact: Samuel Raad       samuel.raad@kliniken-lb.de    Principal Investigator: Karel Caca, MD          Diakoniekrankenhaus Mannheim, Medizinische Klinik II Recruiting Mannheim, Germany, 68163 Contact: Ulrich Damian, MD       u.damian@diako-ma.de    Principal Investigator: Ulrich Damian, MD          II. Medizinische Klinik und Poliklinik der TU München, Klinikum rechts der Isar Recruiting Munich, Germany, 81675 Contact: Jens Zimmermann       Studiensekretariat.med2@lrz.tum.de    Principal Investigator: Jens T. Siveke, MD          Klinik Mühldorf Abt.Gastroenterologie Recruiting Mühldorf am Inn, Germany, 84453 Contact: Melanie Mühlberger       melanie.muehlberger@kliniken-muehldorf.de    Principal Investigator: Gerhard Fuechsl, MD          Klinikum Bogenhausen, Interdisziplinäre Onkologische Tagklinik Recruiting München, Germany, 81525 Contact: Romy Petermann       romy.petermann@klinikum-muenchen.de    Principal Investigator: Martin Fuchs, MD          Regio Kliniken Pinneberg Not yet recruiting Pinneberg, Germany, 25421 Contact: Stefan Tardos, MD       stefan.tardos@regiokliniken.de    Principal Investigator: Stefan Tardos, MD          Klinikum St. Elisabeth, I. Medizinische Klinik Recruiting Straubing, Germany, 94315 Contact: Stefanie Wolf       stefanie.wolf@klinikum-straubing.de    Principal Investigator: Weigert Norbert, MD          Universitätsklinikum Ulm, Klinik für Innere Medizin I Recruiting Ulm, Germany, 89081 Contact: Yvonne Kriebisch       yvonne.kriebisch@uniklinik-ulm.de    Principal Investigator: Goetz von Wichert, MD          Evangelisches Krankenhaus Wesel, Abteilung Innere Medizin Recruiting Wesel, Germany, 46485 Contact: Adelheid Rosendahl       rosendahl@evkwesel.de    Principal Investigator: Dirk Hartnack, MD Collapse <<
  NCT00253643	Precancerous Condition ... more >> Prostate Cancer Collapse <<	Not Applicable	Completed	-	United States, Oregon ... more >> Kaiser Permanente Center for Health Research Portland, Oregon, United States, 97227 OHSU Knight Cancer Institute Portland, Oregon, United States, 97239-3098 Veterans Affairs Medical Center - Portland Portland, Oregon, United States, 97239 Collapse <<
  NCT00917735	Breast Cancer	Phase 2	Completed	-	United States, Minnesota ... more >> Fairview Southdale Breast Center Edina, Minnesota, United States, 55435 Fairview Maple Grove Breast Center Maple Grove, Minnesota, United States, 55369 University of Minnesota Medical Center (UMMC) Breast Clinic Minneapolis, Minnesota, United States, 55455 Park Nicollet Institute St. Louis Park, Minnesota, United States, 55426 Food Science and Nutrition, University of Minnesota St. Paul, Minnesota, United States, 55108 Collapse <<

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• 参考文献

• [1] Hui X, Hua SH, et al. Antimicrobial mechanism of epigallocatechin gallate and gallocatechin gallate: They target 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway. Arch Biochem Biophys. 2017 May 15;622:1-8.

  [2] Takagaki A, Nanjo F. Biotransformation of (-)-epigallocatechin and (-)-gallocatechin by intestinal bacteria involved in isoflavone metabolism. Biol Pharm Bull. 2015;38(2):325-30.

  [3] Siebert DA, Paganelli CJ, Queiroz GS, Alberton MD. Anti-inflammatory activity of the epicuticular wax and its isolated compounds catechin and gallocatechin from Eugenia brasiliensis Lam. (Myrtaceae) leaves. Nat Prod Res. 2021 Nov;35(22):4720-4723

  [4] Vendidandala NR, Yin TP, Nelli G, Pasupuleti VR, Nyamathulla S, Mokhtar SI. Gallocatechin‑silver nanoparticle impregnated cotton gauze patches enhance wound healing in diabetic rats by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways. Life Sci. 2021 Dec 1;286:120019

  [5] Sohail A, Bhat WF, Bhat SA, Furkan M, Shah A, Bano B. Investigating the preventive effects of baicalin and gallocatechin against glyoxal-induced cystatin aggregation. J Biomol Struct Dyn. 2018 Nov;36(14):3791-3802

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