|(2-羟丙基)-β-环糊精|CsnPharm

CAS No.: 128446-35-5

Synonyms: Hydroxypropyl betadex;Hydroxypropyl-β-cyclodextrin;HP-β-CD

HP-β-CD is used to improve the solubility of lipophilic drugs. It is also an inhibitor of amyloid-β aggregation and Aβ-induced toxicity.

规格	价格	促销价格	库存	数量

400-920-2911

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描述2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is a cyclic oligosaccharide that is widely used as an enabling excipient in pharmaceutical formulations, but also as a cholesterol modifier. HP-β-CyD treatment reduced intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. Intraperitoneal injection of HP-β-CyD significantly improved survival in leukemia mouse models^[2]. HPβCD administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder^[3]. HP-β-CD and HP-γ-CD reduce the accumulation of sphingolipids, mainly sphingomyelins, and free cholesterol as well as lysosome changes in Npc1-null, but not in wild-type, CHO cells^[4]. HP-β-CD is well tolerated in the animal species tested (rats, mice and dogs), particularly when dosed orally, and shows only limited toxicity^[5].
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CAS号

128446-35-5

储存条件

分子式

运输

蓝冰

分子量

0.00

别名

Hydroxypropyl betadex;Hydroxypropyl-β-cyclodextrin;HP-β-CD;2-Hydroxypropyl-β-cyclodextrin;107745-73-3;羟丙基-β-环糊精

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