CAS No.: 73069-25-7
(±)-Praeruptorin A/(±)-白花前胡甲素 Catalog No. CSN19953
Synonyms: Praeruptorin-A;(±)-白花前胡甲素
(±)-Praeruptorin A, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation, has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis, and can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Yeon JT, Choi SW, et al. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. J Nat Prod. 2015 Apr 24;78(4):776-82.
- [2] Yeon JT, Kim KJ, et al. Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. PLoS One. 2014 Feb 21;9(2):e88974.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 73069-25-7 | 储存条件 |
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| 分子式 | C21H22O7 | 运输 | 蓝冰 | |
| 分子量 | 386.40 | 别名 | Praeruptorin-A;(±)-白花前胡甲素 |
