|1,3,8-三羟基-6-(羟甲基)蒽-9,10-二酮|CsnPharm

CAS No.: 481-73-2

1,3,8-Trihydroxy-6-(hydroxymethyl)anthracene-9,10-dione Catalog No. CSN14045

Citreorosein, a cAMP phosphodiesterase inhibitor isolated and purified from the root and rhizome of Rheum palmatum L., has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.

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技术信息

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描述Citreorosein, a cAMP phosphodiesterase inhibitor isolated and purified from the root and rhizome of Rheum palmatum L., has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation. Citreorosein attenuates degranulation and LTC(4) generation through the suppression of multiple step signaling and would be beneficial for the prevention of allergic inflammation and strongly inhibits COX-2-dependent PGD2 generation in a concentration-dependent manner in mouse bone marrow-derived mast cells (BMMCs) stimulated with stem cell factor (SCF)/IL-10/LPS.
参考文献

[1] Lu Y, Suh SJ, et al. Citreorosein inhibits production of proinflammatory cytokines by blocking mitogen activated protein kinases, nuclear factor-κB and activator protein-1 activation in mouse bone marrow-derived mast cells. Biol Pharm Bull. 2012;35(6):938-45.
[2] Lu Y, Li Y, et al. Citreorosein inhibits degranulation and leukotriene C₄ generation through suppression of Syk pathway in mast cells. Mol Cell Biochem. 2012 Jun;365(1-2):333-41.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4936 mL
- 17.4681 mL
- 34.9362 mL
- 5 mM
- 0.6987 mL
- 3.4936 mL
- 6.9872 mL
- 10 mM
- 0.3494 mL
- 1.7468 mL
- 3.4936 mL

技术信息

CAS号	481-73-2	储存条件	粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H10O6	运输	蓝冰
分子量	286.24	别名

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1,3,8-Trihydroxy-6-(hydroxymethyl)anthracene-9,10-dione Catalog No. CSN14045

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