CAS No.: 676596-65-9
1-Azakenpaullone Catalog No. CSN18742
Synonyms: 1-Akp
1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, > 100-fold selectivity over CDK1/cyclin B and CDK5/p25.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Liu H, Remedi MS, et al. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes. 2009 Mar;58(3):663-72.
- [2] Kunick C, Lauenroth K, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.
- [3] Kunick C, Lauenroth K, Leost M, Meijer L, Lemcke T. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. doi: 10.1016/j.bmcl.2003.10.062. PMID: 14698171.
- [4] Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, McDaniel ML. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes. 2009 Mar;58(3):663-72. doi: 10.2337/db07-1208. Epub 2008 Dec 10. PMID: 19073772; PMCID: PMC2646065.
- [5] Feng ZC, Donnelly L, Li J, Krishnamurthy M, Riopel M, Wang R. Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice. Lab Invest. 2012 Apr;92(4):543-55. doi: 10.1038/labinvest.2011.200. Epub 2012 Jan 16. PMID: 22249311; PMCID: PMC3940483.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 676596-65-9 | 储存条件 |
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| 分子式 | C15H10BrN3O | 运输 | 蓝冰 | |
| 分子量 | 328.16 | 别名 | 1-Akp |
