|1-乙基-1H-苯并[d]咪唑-2(3H)-酮|CsnPharm

CAS No.: 10045-45-1

1-EBIO Catalog No. CSN25452

Synonyms: 1-Ethyl-2-benzimidazolinone;1-Ethylbenzimidazolinone

Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.

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技术信息

生物活性

描述1-EBIO (the K⁺ channel opener 1-ethyl-2-benzimidazolone) potentiates CFTR-mediated Cl⁻ secretion in cultured cells and mouse colon^[1]. 1-EBIO, an activator of SK4, induced outward K(+) current (ISK4) in SNU-1076 and OSC-19. In HN5, ISK4 was not observed or negligible. The 1-EBIO-induced current was abolished by TRAM-34, a selective SK4 blocker^[2]. EBIO activated apical Cl- channels and basolateral K+ channels (presumably those that are Ca2+ dependent), thereby suggesting that this compound, or related derivatives, may be suitable as topical agents to stimulate fluid transport across the tissue in individuals with lacrimal gland deficiencies^[3]. Under whole-cell patch-clamp recording conditions, 1-EBIO induced a voltage-insensitive, charybdotoxin-sensitive K+ current in cultured endothelial cells but was without effect on K+ currents in smooth muscle cells isolated from hepatic arteries^[4].

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.1657 mL
- 30.8283 mL
- 61.6567 mL
- 5 mM
- 1.2331 mL
- 6.1657 mL
- 12.3313 mL
- 10 mM
- 0.6166 mL
- 3.0828 mL
- 6.1657 mL

技术信息

CAS号	10045-45-1	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C9H10N2O	运输	蓝冰
分子量	162.19	别名	1-Ethyl-2-benzimidazolinone;1-Ethylbenzimidazolinone

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1-EBIO Catalog No. CSN25452

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