|2',3'-cGAMP游离态|CsnPharm

CAS No.: 1441190-66-4

2',3'-cGAMP Catalog No. CSN26922

Synonyms: 2'-3'-cyclic GMP-AMP;cGAMP;C-20640

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].

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生物活性

描述Stimulator of interferon genes (STING; encoded by TMEM173) is a signaling molecule associated with the endoplasmic reticulum (ER) and is essential for controlling the transcription of numerous host defence genes. ^[1]. 2',3'-cGAMP is a second messenger that binds and activates the adaptor protein STING with a Kd value of 3.79 nM, which triggers the innate immune response. It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells. ^[2]. Coinjection of 2′3′-cGAMP (1mg/m; intrathoracic injection) with DCV or the related CrPV resulted in a significant decrease in viral RNA accumulation in WT flies. Accordingly, 2′3′-cGAMP improved the survival of DCV-infected WT flies^[3]. Thousands of genes were induced by 2'3'-cGAMP, many of which are homologs of genes known to function in mammalian immunity in N. vectensis after 24 h treatment (500 μM in bath of 1/3× sea water). Immune gene induction downstream of 2',3'-cGAMP also occur in embryo with lower dose and shorter treatment (100 μM in bath of 1/3× sea water)^[4].
参考文献

[1] Barber, G. N. STING: infection, inflammation and cancer. Nat Rev Immunol. 2015; 15(12): 760-770.
[2] Zhang, X., Shi, H., Wu, J., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell. 2015;51(2), 226-235.
[3] Cai, H., Holleufer, A., Simonsen, B. et al. 2',3'-cGAMP triigers a STING- and NF-κB–dependent broad antiviral response in Drosophila. Science Signalling. 2020;12(660).
[4] Margolis, S. R., Dierzen, P. A. et al. The cyclic dinucleotide 2’3’-cGAMP induces a broad antibacterial and antiviral response in the sea anemone Nematostella vectensis. PNAS. 2021;118(5): e2109022118.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4828 mL
- 7.4139 mL
- 14.8277 mL
- 5 mM
- 0.2966 mL
- 1.4828 mL
- 2.9655 mL
- 10 mM
- 0.1483 mL
- 0.7414 mL
- 1.4828 mL

技术信息

CAS号	1441190-66-4	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C20H24N10O13P2	运输	蓝冰
分子量	674.41	别名	2'-3'-cyclic GMP-AMP;cGAMP;C-20640

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