|(E,E)-二(2-羟基苄亚基)丙酮|CsnPharm

CAS No.: 131359-24-5

2-HBA Catalog No. CSN24780

Synonyms: Bis(2-hydroxybenzylidene)acetone

2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

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技术信息

生物活性

描述Induction of phase 2 response is a powerful and highly efficient strategy for protection against the continual damaging effects of reactive oxygen intermediates and electrophiles, both of which participate in the pathogenesis of cancer and many other chronic diseases. NAD(P)H-quinone acceptor oxidoreductase 1 (NQO1), a Phase 2 enzyme, catalyzes diverse reactions that collectively result in broad protection against electrophiles and oxidant^[1]. 2-HBA (Bis(2-hydroxybenzylidene)acetone), a curcumin analog, induced NQO1 in a concentration-dependent manner with a CD value of 0.15 mM. Treatment with 2-HBA caused cell cycle arrest and apoptosis (caspase-3 and caspase-10) in both murine leukemia cell line L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner^[2]. Also, 2-HBA at 0.25 – 4 μM dose-dependently induced the Nrf2 signaling pathway in HBE cells by blocking ubiquitylation. In A/J mice with lung adenocarcinoma, intraperitoneal injections of BHBA (20 mg/kg) twice over a 3-day period reduced the internal tumor number to nearly 50% compared with the corn oil control ^[3].
参考文献

[1] Dinkova-Kostova AT, Fahey JW, Wade KL, et al. Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev. 2007;16(4):847‐851.
[2] Dinkova-Kostova AT, Cory AH, Bozak RE, Hicks RJ, Cory JG. Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway. Cancer Lett. 2007;245(1-2):341-9
[3] Shen T, Jiang T, Long M, et al. A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response. Antioxid Redox Signal. 2015;23(8):651‐664.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7553 mL
- 18.7765 mL
- 37.5530 mL
- 5 mM
- 0.7511 mL
- 3.7553 mL
- 7.5106 mL
- 10 mM
- 0.3755 mL
- 1.8777 mL
- 3.7553 mL

技术信息

CAS号

131359-24-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H14O3

运输

蓝冰

分子量

266.29

别名

Bis(2-hydroxybenzylidene)acetone

溶解度

DMSO	87.5 mg/mL (328.6 mM)
Water	insoluble

动物实验配方

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2-HBA Catalog No. CSN24780

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