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CAS No.: 121064-78-6

3-O-trans-p-Coumaroyltormentic acid Catalog No. CSN15244

Synonyms: 3-O-p-Coumaroyltormentic Acid

3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia.

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技术信息

生物活性

描述3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively, and is weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4mg/mL and a 50% inhibitory concentration (IC50) of 72.0mg/mL for monkey kidney epithelial (MA104) cells. It also shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).
参考文献

[1] Taniguchi S, Imayoshi Y, et al. Production of bioactive triterpenes by Eriobotrya japonica calli. Phytochemistry. 2002 Feb;59(3):315-23.
[2] Numata A, Yang P, et al. Cytotoxic triterpenes from a Chinese medicine, Goreishi. Chem Pharm Bull (Tokyo). 1989 Mar;37(3):648-51.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5752 mL
- 7.8760 mL
- 15.7520 mL
- 5 mM
- 0.3150 mL
- 1.5752 mL
- 3.1504 mL
- 10 mM
- 0.1575 mL
- 0.7876 mL
- 1.5752 mL

技术信息

CAS号	121064-78-6	储存条件	粉末液体 -20°C:3-6 月 -80°C:12月
分子式	C39H54O7	运输	蓝冰
分子量	634.84	别名	3-O-p-Coumaroyltormentic Acid

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