CAS No.: 364042-47-7
A 419259/RK 20449游离态 Catalog No. CSN18243
Synonyms: RK-20449
A 419259 is an apoptosis inducing agent that inhibits Src family kinases (c-Src) and also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Pene-Dumitrescu T, Peterson LF, et al. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene. 2008 Nov 27;27(56):7055-69.
- [2] Wilson MB, Schreiner SJ, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 364042-47-7 | 储存条件 |
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| 分子式 | C29H34N6O | 运输 | 蓝冰 | |
| 分子量 | 482.62 | 别名 | RK-20449 |
