|S-2-氰基-1-(1-苯乙基)-3-(喹啉-5-基)胍|CsnPharm

CAS No.: 1125758-85-1

A-804598 Catalog No. CSN19020

Synonyms: N/A

A-804598 is a competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively.

规格	价格	促销价格	库存	数量

400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述A-804598 is a structurally novel, competitive and selective P2X7 receptor antagonist with IC50 values of 10nM and 11nM for affinity at rat P2X7 receptor and human P2X7 receptor. A-804598 also potently blocked agonist stimulated release of IL-1β and Yo-Pro uptake from differentiated THP-1 cells that natively express human P2X7 receptors. Antagonization of P2X7 receptor by A-804598 led a block of BzATP-stimulated changes in intracellular calcium concentrations.
作用机制A-804598 can competitively bind to P2X7 receptor.^[1]
动物研究
剂量
Mice: 90 mg/kg^[2] (i.p.)
Rat: 3 mg/kg - 30 mg/kg^[3] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 90 mg/kg^[2] (i.p.) Rat: 3 mg/kg - 30 mg/kg^[3] (i.p.)
给药途径	i.p.

[1] Donnelly-Roberts DL, Namovic MT, et al. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology. 2009 Jan;56(1):223-9.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1709 mL
- 15.8543 mL
- 31.7086 mL
- 5 mM
- 0.6342 mL
- 3.1709 mL
- 6.3417 mL
- 10 mM
- 0.3171 mL
- 1.5854 mL
- 3.1709 mL

技术信息

CAS号

1125758-85-1

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H17N5

运输

蓝冰

分子量

315.37

别名

N/A

溶解度

DMSO	63.0 mg/mL (199.8 mM)
Water	Insoluble
Ethanol	6.0 mg/mL (19.0 mM)

动物实验配方

5%DMSO+ 30%PEG+2% tween80 +H2O

6 mg/mL

clear

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A-804598 Catalog No. CSN19020

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