|(2R,3R,4R,5R,6S)-6-甲基四氢-2H-吡喃-2,3,4,5-四醇水合物|CsnPharm

CAS No.: 6155-35-7

α-L-Rhamnose monohydrate/α-L-鼠李糖一水合物 Catalog No. CSN16003

Synonyms: 6-deoxy-L-mannose monohydrate;α-L-Rhamnose Monohydrate;6-Deoxy-L-mannose

L-Rhamnose, a natural product isolated and purified from the flowers of Scphora japonica L., increases serum propionate after long-term supplementation, but lactulose does not raise serum acetate, has anticancer potential, they exert a significant suppressive effect on tumour growth, and exhibits potent excellent sodium-glucose transporter (SGLT1 and SGLT2) inhibition activity.

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生物活性

描述L-Rhamnose monohydrate (Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies^[3]. Rhamnose monohydrate crosses the epithelia via the transcellular pathway and acts as a marker of intestinal absorption^[4]. The main monosaccharides found in RHWPs were mannose, ribose, l-rhamnose monohydrate, glucuronic acid, galacturonic acid, glucose, galactose, xylose, arabinose, and fucose. RHWPs inhibited the proliferation of S180 tumor cells and induced apoptosis in vitro. Oral administration of RHWPs to tumor-bearing mice significantly inhibited the growth of the S180 xenografts, accelerated apoptosis in tumor cells, and expanded the necrotic regions. Furthermore, RHWPs also markedly increased the levels of TNF-α, IFN-γ, and IL-2 in the sera of tumor-bearing mice, and activated immune cells such as lymphocytes, NK cells, and macrophages, thereby inducing tumor cell apoptosis^[5]. L-rhamnose treatment in 3T3-L1 adipocytes also significantly elevated protein levels of p-HSL, p-AMPK, ACOX, and CPT1 as well as reduced levels of ACC, FAS, C/EBPα, and PPARγ, suggesting its possible role in enhancement of lipolysis and lipid catabolism as well as reduced adipogenesis and lipogenesis, respectively^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.4893 mL
- 27.4466 mL
- 54.8932 mL
- 5 mM
- 1.0979 mL
- 5.4893 mL
- 10.9786 mL
- 10 mM
- 0.5489 mL
- 2.7447 mL
- 5.4893 mL

技术信息

CAS号

6155-35-7

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H14O6

运输

蓝冰

分子量

182.17

别名

6-deoxy-L-mannose monohydrate;α-L-Rhamnose Monohydrate;6-Deoxy-L-mannose;L(+)Rhamnopyranose;α-L-鼠李糖一水合物;鼠李糖

溶解度

DMSO	265.0 mg/mL (1454.7 mM) warming
Water	150.0 mg/mL (823.4 mM)

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α-L-Rhamnose monohydrate/α-L-鼠李糖一水合物 Catalog No. CSN16003

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