|2-((1-(3-氟苯基)环己基)氨基)-N-羟基嘧啶-5-甲酰胺|CsnPharm

CAS No.: 1375466-18-4

ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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描述HDAC6 (histone deacetylase 6) is a structurally and functionally unique class Iib isoform localized almost exclusively to the cytoplasm. HDAC6 loss of function results in an antidepressant-like phenotype. ACE-775 is a potent and selective HDAC6 inhibitor with an IC₅₀ value of 7.5 nM. In RN46A-B14 cells treated with ACY-775 (2.5 μM) for 4 hours, there was an increase in the acetylated (lysine 40) fraction of α-tubulin. ACY-775 rapidly distribute to the brain leading to a total drug exposure in CNS comparable to that of peripheral tissues. In wild-type mice, ACY-775 (50 mg/kg; 24 h, 4 h, and 30 min) caused significant increases in α-tubulin acetylation in all tested brain regions: cortex, hippocampus and cerebellum and stimulated mouse exploratory behaviors in novel environments^[3].
作用机制Activity of ACY-775 is fully explained by inhibition of the C terminal catalytic domain of HDAC6^[3].
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实验方案

技术信息

CAS号

1375466-18-4

储存条件

分子式

C17H19FN4O2

运输

蓝冰

分子量

330.36

别名

溶解度

动物实验配方

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