CAS No.: 1609389-52-7
ACY-957 Catalog No. CSN20189
Synonyms: HDAC Inhibitor C001
HDAC inhibitor C001 is an inhibitor of HDACs with IC50 of 4 nM (HDAC1), 15 nM (HDAC2), 114 nM (HDAC3), and can increase Gata2 expression, which may be useful in treatment of Gata2-deficiency-associated diseases, including leukemia and other blood cell disorders.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Shearstone JR, Golonzhka O, Chonkar A, Tamang D, van Duzer JH, Jones SS, Jarpe MB. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767. doi: 10.1371/journal.pone.0153767. PMID: 27073918; PMCID: PMC4830539.
- [2] Mehraei M, Bashirov R, Tüzmen Ş. Target-based drug discovery for [Formula: see text]-globin disorders: drug target prediction using quantitative modeling with hybrid functional Petri nets. J Bioinform Comput Biol. 2016 Oct;14(5):1650026. doi: 10.1142/S0219720016500268. Epub 2016 Jun 21. PMID: 27431020.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1609389-52-7 | 储存条件 |
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| 分子式 | C24H23N5OS | 运输 | 蓝冰 | |
| 分子量 | 429.54 | 别名 | HDAC Inhibitor C001 |
