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CAS No.: 957230-65-8
Synonyms: D-Isofagomine D-Tartrate;Isofagomine D-Tartrate;Isofagomine (D-tartrate)
Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts.
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技术信息
CAS号 | 957230-65-8 | 储存条件 |
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分子式 | C10H19NO9 | 运输 | 蓝冰 | |
分子量 | 297.26 | 别名 | D-Isofagomine D-Tartrate;Isofagomine D-Tartrate;Isofagomine (D-tartrate);AT-2101;Isofagomine;Afegostat;D-Isofagomine;isoFagomine. brand name: Plicera |
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