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CAS No.: 957230-65-8

Afegostat D-Tartrate Catalog No. CSN26655

Synonyms: D-Isofagomine D-Tartrate;Isofagomine D-Tartrate;Isofagomine (D-tartrate)

Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts.

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CAS号 957230-65-8 储存条件
分子式 C10H19NO9 运输 蓝冰
分子量 297.26 别名 D-Isofagomine D-Tartrate;Isofagomine D-Tartrate;Isofagomine (D-tartrate);AT-2101;Isofagomine;Afegostat;D-Isofagomine;isoFagomine. brand name: Plicera

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