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CAS No.: 866893-90-5

Aftin-4 Catalog No. CSN21167

Synonyms: Aftin-4

Aftin-4 is a potent and selective Aβ42 inducer with an EC50 of 30 μM.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Aftin-4 is an Aβ₁₋₄₂ inducer which could result in a rapid, acute Alzheimer's disease-like toxicity in the rodent brain in vivo. It promoted the generation of amyloid-β (Aβ)₁₋₄₂ from amyloid-β protein precursor through γ-secretase activation in cell cultures. The intracerebroventricular administration of aftin-4 at 3–20nM increased Aβ₁₋₄₂, but not Aβ_1-40, content in the mouse hippocampus, between 5 and 14 days after injection. The treatment provoked marked learning deficits. Also it increased brain contents in pro-inflammatory cytokines, IL-1β, IL-6, and TNFα, and GFAP immunolabeling, showing astrocytic reaction, as well as increased lipid peroxidation levels in the hippocampus, an index of oxidative stress. Expression of the synaptic marker synaptophysin was decreased by aftin-4. The systemic intraperitoneal injection of aftin-4 in the 3-30 mg/kg dose range also induced oxidative stress and learning deficits^[2].
动物研究
剂量
Mice: 3 mg/kg - 30 mg/kg^[1] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 3 mg/kg - 30 mg/kg^[1] (i.p.)
给药途径	i.p.

[1] Meunier J, Borjini N, et al. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative. J Alzheimers Dis. 2015;44(2):507-24.
[2] Meunier J, Borjini N, Gillis C, Villard V, Maurice T. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative. J Alzheimers Dis. 2015;44(2):507-24. doi: 10.3233/JAD-140711. PMID: 25298201.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7139 mL
- 13.5694 mL
- 27.1388 mL
- 5 mM
- 0.5428 mL
- 2.7139 mL
- 5.4278 mL
- 10 mM
- 0.2714 mL
- 1.3569 mL
- 2.7139 mL

技术信息

CAS号

866893-90-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H28N6O

运输

蓝冰

分子量

368.48

别名

Aftin-4

溶解度

DMSO	500.0 mg/mL (1356.9 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	10 mg/mL	clear
PO	0.5% CMC-Na	63 mg/mL	suspension

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