|(S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-咪唑-4-基)甲基)-6-((1H-吲哚-3-基)甲基)-21-(3-胍基丙基)-12-(4-羟基苄基)-9-(羟基甲基)-18-异丁基15甲基1,4,7,10,13,16,19-七氧代-1-((S)-5-氧代吡咯烷-2-基)-2,5,8,11,14,17,20-七氮杂多糖-22-羟基)-N-乙基吡咯烷-2-甲酰胺二乙酸酯|CsnPharm

CAS No.: 79561-22-1

Alarelin Acetate/醋酸丙氨瑞林 Catalog No. CSN11805

Synonyms: 醋酸阿拉瑞林

Alarelin acetate is a synthetic agonist of GnRH.

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实验方案

技术信息

生物活性

描述Alarelin Acetate is the acetate form of Alarelin. Alarelin is a GnRH (gonadotropin-releasing hormone) analog. It directly inhibited proliferation and DNA synthesis of rat GSMC through GnRH receptors at 1nM, 0.1μM and 10μM^[3]. Administration of Alarelin at 2μg/kg could inhibit the gastric acid secretion both by direct actions on parietal cells and by inhibiting vagous function^[4].
作用机制Alarelin is a GnRH (gonadotropin-releasing hormone) analog.^[3]
动物研究
剂量
Rabbit: 1 µg/kg^[3] (i.v.)

给药途径
i.v.
参考文献

动物研究
剂量	Rabbit: 1 µg/kg^[3] (i.v.)
给药途径	i.v.

[1] Chen L, He HX, et al. Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats. World J Gastroenterol. 2004 Jun 15;10(12):1780-4.
[2] Chen L, Sun XD, et al. Distribution, cloning and sequencing of GnRH, its receptor, and effects of gastric acid secretion of GnRH analogue in gastric parietal cells of rats. Life Sci. 2005 Feb 4;76(12):1351-65.
[3] Chen L, He HX, Sun XD, Zhao J, Liu LH, Huang WQ, Zhang RQ. Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats. World J Gastroenterol. 2004 Jun 15;10(12):1780-4. doi: 10.3748/wjg.v10.i12.1780. PMID: 15188505; PMCID: PMC4572268.
[4] Chen L, Sun XD, Zhao J, Yang AG, Huang WQ. Distribution, cloning and sequencing of GnRH, its receptor, and effects of gastric acid secretion of GnRH analogue in gastric parietal cells of rats. Life Sci. 2005 Feb 4;76(12):1351-65. doi: 10.1016/j.lfs.2004.10.005. PMID: 15670615.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.7767 mL
- 3.8837 mL
- 7.7675 mL
- 5 mM
- 0.1553 mL
- 0.7767 mL
- 1.5535 mL
- 10 mM
- 0.0777 mL
- 0.3884 mL
- 0.7767 mL

技术信息

CAS号

79561-22-1

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C60H86N16O16

运输

蓝冰

分子量

1287.42

别名

醋酸阿拉瑞林

溶解度

DMSO	95.0 mg/mL (73.8 mM) warming
Water	100.0 mg/mL (77.7 mM) warming

动物实验配方

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Alarelin Acetate/醋酸丙氨瑞林 Catalog No. CSN11805

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