39011-90-0|Albiflorin|CsnPharm

CAS No.: 39011-90-0

Albiflorin/芍药内酯苷 Catalog No. CSN10185

Synonyms: OA10410;芍药内酯苷

Albiflorin is a natural product isolated and purified from the roots of Paeonia albiflora. It is also a major constituent contained in peony root which possesses therapeutic potential for neurodegenerative diseases.

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400-920-2911

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技术信息

生物活性

描述The root of Paeonia lactiflora Pall (family Ranunculaceae) or peony root is a commonly used Chinese herbal medicine in clinical practice. Empirical evidence suggests that various peony root preparations have broad therapeutic benefits for pain, muscle spasm, inflammation, menstrual dysfunction, and neurodegenerative disorder. The isomer albiflorin (AF) is a major constituent contained in peony root. Pretreatment with AF at 50 μM and 100 μM significantly reduced the lethal effect of Glu (P<0.05). Pretreatment with 100 μM AF almost completely inhibited Glu-induced apoptotic alternation, with a >93 % of survival rate compared to 84 % in untreated cells (P<0.05). Moreover, Glu-induced increase of ROS level was suppressed to control level by 100 μM AF pretreatment (P<0.05), suggesting that the protective effect of AF against Glu neurotoxicity are associated with the reduction of intracellular ROS level. In the presence of 100 μM AF, the phosphorylation of AKT and GSK3β was up-regulated in a time-dependent manner (P<0.05) indicating that the activation of AKT/GSK-3β is associated with the protective effects of AF against Glu neurotoxicity^[3].
参考文献

[1] Wang QS, Gao T, et al. Comparative studies of paeoniflorin and albiflorin from Paeonia lactiflora on anti-inflammatory activities. Pharm Biol. 2014 Sep;52(9):1189-95.
[2] Sheng Y, Li L, et al. Simultaneous determination of albiflorin and paeoniflorin in rat urine by solid-phase extraction and high-performance liquid chromatography following oral administration of Si-Wu decoction. Biomed Chromatogr. 2004 Dec;18(10):785-90.
[3] Wang D, Tan QR, Zhang ZJ. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013;51(2):581‐590

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0813 mL
- 10.4067 mL
- 20.8133 mL
- 5 mM
- 0.4163 mL
- 2.0813 mL
- 4.1627 mL
- 10 mM
- 0.2081 mL
- 1.0407 mL
- 2.0813 mL

技术信息

CAS号

39011-90-0

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H28O11

运输

蓝冰

分子量

480.46

别名

OA10410;芍药内酯苷

溶解度

DMSO	96.0 mg/mL (199.8 mM)

动物实验配方

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