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CAS No.: 1050500-29-2
Synonyms: AST-1306 (TsOH);AST-6 p-Toluenesulfonic Acid;AST p-Toluenesulfonic Acid
AST-1306 p-toluenesulfonic acid is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
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实验方案
技术信息
CAS号 | 1050500-29-2 | 储存条件 |
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分子式 | C31H26ClFN4O5S | 运输 | 蓝冰 | |
分子量 | 621.08 | 别名 | AST-1306 (TsOH);AST-6 p-Toluenesulfonic Acid;AST p-Toluenesulfonic Acid;AST-1306 (tosylate);Allitinib;AST-1306 TsOH;ALS-1306 TsOH;AST-6 TsOH;艾力替尼;AST-1306 (TsOH |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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A431 cells | - | Proliferation assay | 72 h | Antiproliferative activity against human A431 cells over-expressing EGFR gene after 72 hrs by SRB assay, IC50=0.2 μM | 22227214 |
A549 cells | - | Proliferation assay | 72 h | Antiproliferative activity against human A549 cells over-expressing EGFR gene after 72 hrs by SRB assay, IC50=6.8 μM | 22227214 |
NCI-H1975 cells | - | Proliferation assay | 72 h | Antiproliferative activity against human NCI-H1975 cells over-expressing EGFR mutant gene after 72 hrs by SRB assay, IC50=0.7 μM | 22227214 |
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