生物活性

• 描述Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01954589	Safety Tolera... more >>bility Pharmacodynamics Pharmacokinetics Collapse <<	Phase 1	Completed	-	Netherlands ... more >> Centre for Human Drug Research Leiden, Netherlands, 2333 CL Collapse <<
  NCT01243060	Healthy Volunteers	Not Applicable	Completed	-	United States, California ... more >> San Francisco Veterans Affairs Medical Center San Francisco, California, United States, 94121 Collapse <<
  NCT00606593	Chronic Primary Insomnia	Phase 2	Completed	-	United States, Arkansas ... more >> Central Arkansas Research Hot Springs, Arkansas, United States, 71913 United States, California Pacific Sleep Medicine Services, Inc. Los Angeles, California, United States, 90048 Pacific Sleep Medicine Services, Inc. San Diego, California, United States, 92121 California Clinical Trials Medical Group, Inc. San Diego, California, United States, 92123 United States, Florida PAB Clinical Research Brandon, Florida, United States, 33511 Miami Research Associates Miami, Florida, United States, 33173 OmniTrials Naples, Florida, United States, 34110 Broward Research Group & Sleep-Wake Disorders Center of South Florida Pembroke Pines, Florida, United States, 33026 United States, Georgia Neurotrials Research, Inc. Atlanta, Georgia, United States, 30342 Sleep Disorders Center of Georgia Atlanta, Georgia, United States, 30342 United States, Kansas Vince and Associates Clinical Research Overland Park, Kansas, United States, 66212 United States, Kentucky Community Research Crestview Hills, Kentucky, United States, 41017 United States, Michigan Clinical Neurophysiology Services, P.C. Troy, Michigan, United States, 48098 United States, Missouri Sleep Disorders & Research Center Chesterfield, Missouri, United States, 63017 United States, Nevada Clinical Research Center of Nevada Las Vegas, Nevada, United States, 89104 United States, North Carolina Duke University Durham, North Carolina, United States, 27710 United States, Ohio Tri-State Sleep Disorders Center Cincinnati, Ohio, United States, 45227 Cleveland Clinic Health Systems Cleveland, Ohio, United States, 44195 United States, Oklahoma Lynn Health Sciences Institute Oklahoma City, Oklahoma, United States, 73112 United States, South Carolina Sleep Disorders Center Columbia, South Carolina, United States, 29201 United States, Texas Sleep Medicine Associates P.A. Dallas, Texas, United States, 75231 Collapse <<

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• 参考文献

• [1] Cruz HG, Hoever P, et al. Assessment of the abuse liability of a dual orexin receptor antagonist: a crossover study of almorexant and zolpidem in recreational drug users. CNS Drugs. 2014 Apr;28(4):361-72.

  [2] Malherbe P, Borroni E, et al. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor(OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol. 2009 Sep;76(3):618-31.