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CAS No.: 473-08-5

alpha-Cyperone/α-香附酮 Catalog No. CSN17004

Synonyms: α-Cyperone;(+)-α-Cyperone;Eudesma-4,11-Dien-3-One

α-Cyperone, a natural product isolated and purified from the hizomes of Cyperus rotundus L., is associated with the down-regulation of COX-2,IL-6,Nck-2,Cdc42 and Rac1, resulting in reduction of inflammation.

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描述α-Cyperone, extracted from Cyperus rotundus, can inhibit microglia-mediated neuroinflammation. α-cyperone substantially decreased H2O2-induced death, release of LDH, and the production of ROS in SH-SY5Y cells. α-cyperone attenuated H2O2-induced cellular apoptosis. Moreover, α-cyperone remarkably reduced the expression of cleaved-caspase-3 and Bax, and upregulated Bcl-2. Furthermore, α-cyperone enhanced the nuclear translocation of Nrf2^[3]. The anti-inflammatory activity of α-cyperone is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells^[4]. In addition, in vivo studies based on a mouse model of arthritis showed that α-Cyperone prevented the development of osteoarthritis^[5]. In addition, α-cyperone is also a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium^[6].
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计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.5801 mL
- 22.9006 mL
- 45.8013 mL
- 5 mM
- 0.9160 mL
- 4.5801 mL
- 9.1603 mL
- 10 mM
- 0.4580 mL
- 2.2901 mL
- 4.5801 mL

技术信息

CAS号	473-08-5	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H22O	运输	蓝冰
分子量	218.33	别名	α-Cyperone;(+)-α-Cyperone;Eudesma-4,11-Dien-3-One;α-香附酮

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