生物活性

• 描述Mutations in ELANE, the gene for neutrophil elastase (NE), a protease expressed early in neutrophil development, are the most frequent cause of cyclic (CyN) and severe congenital neutropenia (SCN)^[3]. Alvelestat is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC₅₀ value of 7.9 nM, a K_i value of 9.4 nM and a K_d value of 9.5 nM^[4]. Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-αin vitro^[5]. Alvelestat (1 - 10 mg/kg; oral administration; twice daily; for 4 days; female BALB/cJBomTac mice) treatment reduces the inflammatory response to cigarette smoke as indicated by a reduction in BAL neutrophils and interleukin-1βin vivo^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03679598	Alpha-1 Antitrypsin Deficiency... more >> (AATD) Pi*ZZ, Pi*SZ, or Pi*Null Phenotype Emphysema or COPD Collapse <<	Phase 2	Not yet recruiting	August 2021	United States, Alabama ... more >> The University of Alabama at Birmingham Lung Health Center Not yet recruiting Birmingham, Alabama, United States, 35294 Contact: Mark M Dransfield, MD    205-934-5555    mdransfield@uabmc.edu Collapse <<
  NCT03636347	Alpha 1-Antitrypsin Deficiency... more >> Emphysema COPD Collapse <<	Phase 2	Recruiting	October 30, 2019	United States, Alabama ... more >> University of Alabama, Birmingham (UAB) Recruiting Birmingham, Alabama, United States, 35294 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    United States, California UC Davis Medical Centre Not yet recruiting Sacramento, California, United States, 95817 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    United States, North Carolina PMG Research of Wilmington Recruiting Wilmington, North Carolina, United States, 28401 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Canada, Alberta The University Lung Clinic Not yet recruiting Edmonton, Alberta, Canada, T6G 2C8 Contact: Ian Hodgson       enquiries@mereobiopharma.com    Canada, British Columbia Centre for Heart Lung Innovation, St Pauls Hospital Not yet recruiting Vancouver, British Columbia, Canada, V6Z 1Y6 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Canada, Ontario Inspiration Research Ltd Recruiting Toronto, Ontario, Canada, M5T 3A9 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Canada, Saskatchewan University of Saskatchewan Royal University Hospital Not yet recruiting Saskatoon, Saskatchewan, Canada, S7N 0W8 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Denmark Aarhus Universitetshospital Not yet recruiting Aarhus, Denmark, 8200 Contact: Ian Hodgson, PhD       Enquiries@mereobiopharma.com    Gentofte Hospital Not yet recruiting Hellerup, Denmark, 2900 Contact: Ian Hodgson       Enquiries@mereobiopharma.com    Synddansk Universitet (SDU) - Odense University Not yet recruiting Odense, Denmark, 5000 Contact: Ian Hodgson       enquiries@mereobiopharma.com    Poland Instytut Gruzilicy Chorob Pluc Not yet recruiting Warsaw, Poland, 01-138 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Sweden CTC Gothia Forum Sahlgrenska University Hospital Not yet recruiting Gothenburg, Sweden, 41345 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Lund University Hospital Not yet recruiting Lund, Sweden, 22185 Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    United Kingdom University Hospitals Birmingham NHS Foundation Trust Not yet recruiting Birmingham, United Kingdom, B15 2GW Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Cambridge University Hospitals Foundation NHS Trust Not yet recruiting Cambridge, United Kingdom, CB2 0QQ Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    University Hospital Coventry and Warwickshire Not yet recruiting Coventry, United Kingdom, CV2 2DX Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Royal Infirmary of Edinburgh Not yet recruiting Edinburgh, United Kingdom, EH16 4TJ Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    University Hospitals of Leicester NHS Trust Not yet recruiting Leicester, United Kingdom, LE1 7RH Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Royal Brompton Hospital Not yet recruiting London, United Kingdom, SWP 6NP Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com    Southampton General Hospital Not yet recruiting Southampton, United Kingdom, SO16 6YD Contact: Ian Hodgson, PhD       enquiries@mereobiopharma.com Collapse <<