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CAS No.: 22862-76-6

Anisomycin/茴香霉素 Catalog No. CSN10317

Synonyms: Flagecidin;Wuningmeisu C;NSC-76712

Anisomycin is a naturally occuring antibiotic which can act as a potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAPK, and also can inhibit protein synthesis by blocking translation.

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实验方案

技术信息

生物活性

描述c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinases (MAPK) family. Anisomycin is an activator of both JNK and p38^[3]. The incubation of HL-1 myocytes with 50ng/mL anisomycin for 24 h markedly increased the protein level of CaMKIIδ by ∼60% relative to the control group. The c-jun phosphorylation in total cell lysates and nuclear extracts was also increased by the treatment of 50ng/mL HL-1 myocytes with anisomycin for 24 h^[4]. The intraperitoneal injection of wild-type, TNFR p55/p75^-/-, and Nox2^-/- mice with 0.1mg/kg anisomycin resulted in the activation of p38, an increase in the production of TNF-α and Nox2, and the phosphorylation of Nox2 compared with the control group^[5].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
HEK293 cells	-	Cytotoxic assay	-	Inhibitory concentration required to produce cytotoxicity against HEK293 cells, IC50=0.02 μM	16005213
human HeLa cells	10 μM	Function assay	-	Inhibition of translation in human HeLa cells at 10 uM by 35S-methionine metabolic labeling study	15165136
mouse RAW264.7 cells	5 μM	Function assay	30 mins	Activation of p38MAPK in mouse RAW264.7 cells assessed as phosphorylation at Thr180/Tyr182 at 5 uM after 30 mins by Western blotting analysis	23294286

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7692 mL
- 18.8462 mL
- 37.6925 mL
- 5 mM
- 0.7538 mL
- 3.7692 mL
- 7.5385 mL
- 10 mM
- 0.3769 mL
- 1.8846 mL
- 3.7692 mL

技术信息

CAS号

22862-76-6

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H19NO4

运输

蓝冰

分子量

265.31

别名

Flagecidin;Wuningmeisu C;NSC-76712;AI3-50846;茴香霉素

溶解度

DMSO	155.0 mg/mL (584.2 mM)
Water	insoluble

动物实验配方

2% DMSO+corn oil

5 mg/mL

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Anisomycin/茴香霉素 Catalog No. CSN10317

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