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CAS No.: 91531-30-5

Antineoplaston A10/抗肿瘤素A10 Catalog No. CSN24051

Synonyms: ANP-A-10;抗肿瘤素 A10

Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.

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技术信息

生物活性

描述Antineoplaston A10 intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis. Antineoplaston A10 also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. It is originally isolate from human urine but is now synthetically derived. It has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver cancer, and Kidney Cancer, among others. The experiment among patient with HBSG suggest to use A10 9.22g/kg/d with AS2-1 0.31g/kg/d for over 5 months, and the overall survival at 2 and 5 years was 39% and 22%^[2].
参考文献

[2] Burzynski, S. R. et al. Targeted Therapy With Antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma. Sage journals. 2006.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0607 mL
- 20.3036 mL
- 40.6072 mL
- 5 mM
- 0.8121 mL
- 4.0607 mL
- 8.1214 mL
- 10 mM
- 0.4061 mL
- 2.0304 mL
- 4.0607 mL

技术信息

CAS号

91531-30-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H14N2O3

运输

蓝冰

分子量

246.26

别名

ANP-A-10;抗肿瘤素 A10

溶解度

DMSO	49.0 mg/mL (199.0 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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